{"id":27121,"date":"2026-09-09T16:01:45","date_gmt":"2026-09-09T20:01:45","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?p=27121"},"modified":"2026-09-09T16:08:34","modified_gmt":"2026-09-09T20:08:34","slug":"inside-ees-newest-research-grants-tackling-the-barriers-to-cf-breakthroughs","status":"publish","type":"post","link":"https:\/\/www.emilysentourage.org\/tr\/inside-ees-newest-research-grants-tackling-the-barriers-to-cf-breakthroughs\/","title":{"rendered":"EE\u2019nin En Yeni Ara\u015ft\u0131rma Hibeleri: Kistik Fibrozis At\u0131l\u0131mlar\u0131n\u0131n \u00d6n\u00fcndeki Engellerin \u00dcstesinden Gelmek"},"content":{"rendered":"

\"\"<\/p>\n

Son 10% kapsam\u0131nda, yeni fon sa\u011flanan alt\u0131 proje, bu alandaki en zorlu sorunlar\u0131n baz\u0131lar\u0131na y\u00f6nelik umut verici \u00e7\u00f6z\u00fcmler geli\u015ftirmeye \u00e7al\u0131\u015f\u0131yor.<\/span><\/i><\/p>\n

 <\/p>\n

Gen d\u00fczenleme ara\u00e7lar\u0131n\u0131 kal\u0131n KF mukusundan ge\u00e7irmek. Genetik olarak d\u00fczeltilmi\u015f h\u00fccrelerin hayatta kalmas\u0131na ve sa\u011fl\u0131kl\u0131 dokuyu yeniden in\u015fa etmesine yard\u0131mc\u0131 olmak. Diren\u00e7li bakterilerin savunmalar\u0131n\u0131 k\u0131rmak ve hatta antibiyotiklerin yeniden \u00e7al\u0131\u015fmas\u0131n\u0131 sa\u011flaman\u0131n yollar\u0131n\u0131 bulmak.<\/b><\/p>\n

Bunlar, Emily's Entourage'\u0131n (EE) en son ara\u015ft\u0131rma fonu turu arac\u0131l\u0131\u011f\u0131yla ara\u015ft\u0131rmac\u0131lar\u0131n ele ald\u0131\u011f\u0131 zorluklardan sadece birka\u00e7\u0131.<\/span><\/p>\n

Alt\u0131 yeni boyunca <\/span>\u00c7eviri Ara\u015ft\u0131rma Hibeleri<\/span><\/a>, bilim insanlar\u0131, kal\u0131c\u0131 ve ilaca diren\u00e7li akci\u011fer enfeksiyonlar\u0131yla m\u00fccadele etmek i\u00e7in yeni yakla\u015f\u0131mlar ararken, gen tedavilerindeki kritik engelleri a\u015fmak amac\u0131yla teknolojiler geli\u015ftiriyor.\u00a0<\/span><\/p>\n

Stratejiler farkl\u0131, ancak ama\u00e7 ayn\u0131: <\/span>Mevcut mutasyona y\u00f6nelik tedavilerden fayda g\u00f6remeyen kistik fibroz (CF) hastalar\u0131 i\u00e7in umut vaat eden bilimsel geli\u015fmeleri somut at\u0131l\u0131mlara d\u00f6n\u00fc\u015ft\u00fcrmek.\u00a0<\/b><\/p>\n

\u0130\u015fte EE'nin en yeni fon sa\u011flanan ara\u015ft\u0131rmac\u0131lar\u0131n\u0131n ne \u00fczerinde \u00e7al\u0131\u015ft\u0131\u011f\u0131na ve bunun neden \u00f6nemli oldu\u011funa daha yak\u0131ndan bir bak\u0131\u015f.<\/strong><\/h5>\n

 <\/p>\n

\"\"Kistik Fibrozis Mukusunun \u00dcstesinden Gelmek<\/b><\/h3>\n

Doktor Xizhen Lian, Johns Hopkins \u00dcniversitesi, Doktor Justin Hanes ile birlikte<\/b><\/p>\n

Koyu ve yap\u0131\u015fkan KF mukusu, tedavilerin ula\u015fmas\u0131 gereken h\u00fccrelere ula\u015fmas\u0131n\u0131 engelleyebilir. Dr. Lian ve Dr. Hanes, \u015fu ad\u0131 verilen minik da\u011f\u0131t\u0131m ara\u00e7lar\u0131 geli\u015ftiriyorlar: <\/span>lipit nanopartik\u00fcller (LNPs) <\/b>\u00f6zellikle mukus i\u00e7inde hareket etmek ve gen d\u00fczenleme tedavilerini do\u011frudan solunum yolu h\u00fccrelerine ta\u015f\u0131mak i\u00e7in tasarlanm\u0131\u015ft\u0131r.<\/span><\/p>\n

Neden \u00f6nemli:<\/b> Mukus bariyerini a\u015fmak, Kistik Fibrozis'i (KF) kayna\u011f\u0131nda tedavi edebilecek genetik terapilerin serbest b\u0131rak\u0131lmas\u0131na yard\u0131mc\u0131 olabilir.<\/span><\/p>\n

Ara\u015ft\u0131rmay\u0131 inceleyin \u2192\u00a0<\/b><\/a><\/p>\n

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\"\"Daha \u0130yi Bir Teslimat Arac\u0131 \u00dcretmek<\/b><\/h3>\n

Doktor Zheng-Rong Lu, Case Western Reserve \u00dcniversitesi<\/b><\/p>\n

Dr. Lu, gen d\u00fczenleme makinelerini do\u011frudan h\u00fccrelerin i\u00e7ine g\u00fcvenli ve verimli bir \u015fekilde ta\u015f\u0131mak i\u00e7in tasarlanm\u0131\u015f yeni t\u00fcrde biyobozunur bir LNP geli\u015ftirmektedir. Ekip, bu yakla\u015f\u0131m\u0131 ba\u015flang\u0131\u00e7ta bir fare modelinde test edecektir. <\/span>sa\u00e7mal\u0131k<\/b> mutasyon<\/b>, CFTR i\u015flevini ba\u015far\u0131yla d\u00fczeltip d\u00fczeltemeyece\u011fini ve eski haline getirip getiremeyece\u011fini de\u011ferlendirerek.<\/span><\/p>\n

Neden \u00f6nemli:<\/b> Gen d\u00fczenleme, ara\u00e7lar g\u00fcvenli bir \u015fekilde ihtiya\u00e7 duyulan h\u00fccrelere ula\u015f\u0131p i\u00e7eri girebildi\u011fi takdirde uygulanabilir bir tedavi haline gelebilir. Bu proje, bu bo\u015flu\u011fu doldurmaya yard\u0131mc\u0131 olmay\u0131 ama\u00e7lamaktad\u0131r.<\/span><\/p>\n

Ara\u015ft\u0131rmay\u0131 inceleyin \u2192\u00a0<\/b><\/a><\/p>\n

 <\/p>\n

<\/h3>\n

\"\"<\/b><\/h3>\n

 <\/p>\n

Yapay Zekay\u0131 \u0130\u015f Ba\u015f\u0131na Ge\u00e7irmek<\/b><\/h3>\n

Doktor Jacob Witten, Massachusetts Teknoloji Enstit\u00fcs\u00fc<\/b><\/p>\n

Dr. Witten kullan\u0131yor <\/span>yapay zeka (AI) ve akci\u011fer biyolojisinin geli\u015fmi\u015f laboratuvar modelleri<\/b> inhale edilebilir genetik tedaviler i\u00e7in \u00f6zel olarak tasarlanm\u0131\u015f LNP'leri h\u0131zla taramak ve belirlemek. Ama\u00e7; etki g\u00fcc\u00fcn\u00fc art\u0131ran, toksisiteyi azaltan ve terap\u00f6tik y\u00fcklerini verimli bir \u015fekilde ula\u015ft\u0131rmak i\u00e7in KF mukozas\u0131na n\u00fcfuz edebilen da\u011f\u0131t\u0131m sistemleri bulmakt\u0131r.<\/span><\/p>\n

Neden \u00f6nemli:<\/b> Yapay zekay\u0131 daha iyi da\u011f\u0131t\u0131m sistemleri aray\u0131\u015f\u0131n\u0131 h\u0131zland\u0131rmak i\u00e7in kullanmak, ara\u015ft\u0131rmac\u0131lar\u0131n tarad\u0131klar\u0131 LNP say\u0131s\u0131n\u0131 katlanarak art\u0131rmas\u0131n\u0131 sa\u011flarken bu taramalar\u0131n maliyetini d\u00fc\u015f\u00fcrecektir.<\/span><\/p>\n

Ara\u015ft\u0131rmay\u0131 inceleyin \u2192\u00a0<\/b><\/a><\/p>\n

 <\/p>\n

\"\"<\/b><\/h3>\n

<\/h3>\n

D\u00fczeltilmi\u015f H\u00fccrelerin Tutunmas\u0131na Yard\u0131m Etmek<\/b><\/h3>\n

Sriram Vaidyanathan, PhD, Nationwide Children\u2019s Hospital ve The Ohio State University, Kyle Cromer, PhD, University of California, San Francisco ile birlikte<\/b><\/p>\n

Dr. Vaidyanathan ve Dr. Cromer tasarlanm\u0131\u015f <\/span>\u201csentetik resept\u00f6rler\u201d<\/b> bu, d\u00fczeltilmi\u015f havayolu k\u00f6k h\u00fccrelerine a\u00e7\u0131l\u0131p kapat\u0131labilen ge\u00e7ici bir b\u00fcy\u00fcme avantaj\u0131 sa\u011flar. Ama\u00e7, bu onar\u0131lan h\u00fccrelerin b\u00fcy\u00fcmesine, yeniden \u00e7o\u011falmas\u0131na ve nihayetinde havayolunu onarmas\u0131na yard\u0131mc\u0131 olmakt\u0131r.<\/span><\/p>\n

Neden \u00f6nemli:<\/b> D\u00fczeltilmi\u015f h\u00fccrelerin kal\u0131c\u0131 olmas\u0131n\u0131 ve dokuyu yeniden in\u015fa etmesini sa\u011flamak, kistik fibrozis hastas\u0131 olan herkesin akci\u011fer sa\u011fl\u0131\u011f\u0131n\u0131 yeniden kazand\u0131ran gelecekteki gen bazl\u0131 tedavileri daha kal\u0131c\u0131 hale getirebilir.<\/span><\/p>\n

Ara\u015ft\u0131rmay\u0131 inceleyin \u2192\u00a0<\/b><\/a><\/p>\n

 <\/p>\n

 <\/p>\n

\"\"Bakterilerin Savunmalar\u0131n\u0131 K\u0131rma<\/b><\/h3>\n

Hugh Smyth, PhD, Teksas \u00dcniversitesi at Austin<\/b><\/p>\n

Dr. Smyth, i\u00e7in solunabilir bir tedavi geli\u015ftirmektedir <\/span>metisiline diren\u00e7li <\/b>Staphylococcus aureus<\/i><\/b> (MRSA)<\/b> bu, bir antibiyoti\u011fi, bakterilerin hayatta kalmak i\u00e7in kulland\u0131\u011f\u0131 koruyucu biyofilmleri par\u00e7alayan biyofilm da\u011f\u0131t\u0131c\u0131 bir enzimle e\u015fle\u015ftirir. \u0130kisini birlikte sunmak, antibiyoti\u011fin, ya\u015fam tehdit edici olabilen ve tedavisi zor bakterileri daha etkili bir \u015fekilde \u00f6ld\u00fcrmesine yard\u0131mc\u0131 olabilir.<\/span><\/p>\n

Neden \u00f6nemli:<\/b> Bakterinin savunmas\u0131n\u0131 ayn\u0131 anda \u00e7\u00f6kertip bir antibiyotikle sald\u0131rarak sald\u0131rmak, inat\u00e7\u0131 ve ya\u015fam tehdit edici MRSA enfeksiyonlar\u0131n\u0131 tedavi etmek i\u00e7in daha etkili bir yol sa\u011flayabilir.<\/span><\/p>\n

Ara\u015ft\u0131rmay\u0131 inceleyin \u2192\u00a0<\/b><\/a><\/p>\n

 <\/p>\n

\"\"Antibiyotikleri Yeniden \u00c7al\u0131\u015f\u0131r Hale Getirmek<\/b><\/h3>\n

Dr. David T. Pride, MD, PhD, Kaliforniya \u00dcniversitesi San Diego T\u0131p Fak\u00fcltesi<\/b><\/p>\n

Dr. Pride, antibiyotikleri \u015fununla e\u015fle\u015ftiriyor: <\/span>ila\u00e7 direncini ele almak i\u00e7in bakteriyofajlar -veya \u201cfajlar\u201d, \u00e7evrede bulunan ve \u00f6zellikle zararl\u0131 bakterileri hedef al\u0131p \u00f6ld\u00fcren vir\u00fcsler- <\/b>Achromobacter<\/i><\/b> enfeksiyonlar, <\/b>KF hastalar\u0131nda giderek artan bir sorun olan<\/span>.<\/b> Erken bulgular, belirli faj-antibiyotik kombinasyonlar\u0131n\u0131n, \u00f6nceden diren\u00e7li bakterileri, \u00f6nceki duyarl\u0131l\u0131k durumlar\u0131na bak\u0131lmaks\u0131z\u0131n ortadan kald\u0131rabilece\u011fini ve hatta yeniden antibiyoti\u011fe duyarl\u0131 hale getirebilece\u011fini g\u00f6stermektedir.<\/span><\/p>\n

Neden \u00f6nemli:<\/b> E\u011fer fajlar, daha \u00f6nce diren\u00e7 kazanm\u0131\u015f antibiyotiklerin etkinli\u011fini yeniden sa\u011flamaya yard\u0131mc\u0131 olabilirse, bu yakla\u015f\u0131m, tedavisi en zor Kistik Fibrozis (KF) enfeksiyonlar\u0131ndan baz\u0131lar\u0131yla kar\u015f\u0131 kar\u015f\u0131ya kalan ki\u015filer i\u00e7in yeni tedavi se\u00e7enekleri yaratabilir.<\/span><\/p>\n

Ara\u015ft\u0131rmay\u0131 inceleyin \u2192\u00a0<\/b><\/a><\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

Emily's Entourage taraf\u0131ndan verilen t\u00fcm hibeleri ke\u015ffedin<\/strong> \u2192 <\/span>https:\/\/www.emilysentourage.org\/awarded-grants\/<\/span><\/a>\u00a0<\/span><\/h3>\n



<\/p>","protected":false},"excerpt":{"rendered":"

Alt\u0131 yeni finanse edilen proje, bu alandaki en zorlu sorunlar\u0131n baz\u0131lar\u0131na y\u00f6nelik umut verici \u00e7\u00f6z\u00fcmleri son 10% y\u0131l boyunca s\u00fcrd\u00fcr\u00fcyor. Gen d\u00fczenleme ara\u00e7lar\u0131n\u0131 kal\u0131n CF mukusunda bulmak; genetik olarak d\u00fczeltilmi\u015f h\u00fccrelerin hayatta kalmas\u0131n\u0131 ve sa\u011fl\u0131kl\u0131 dokuyu yeniden olu\u015fturmas\u0131n\u0131 sa\u011flamak; diren\u00e7li bakterilerin savunmalar\u0131n\u0131 y\u0131kmak \u2013 hatta antibiyotiklerin tekrar etki yapmas\u0131n\u0131 sa\u011flamaya y\u00f6nelik yollar bulmak \u2013 bunlar bunlardan baz\u0131lar\u0131d\u0131r\u2026 <\/p>\n

<\/div>\n

Daha fazla bilgi edinin<\/a><\/p>","protected":false},"author":1719,"featured_media":27143,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[197,217,223,204,275,274,271,188,270],"class_list":["post-27121","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-cf-research","tag-cf-science","tag-ee-grant","tag-ee-research","tag-emilys-entourage-grant","tag-emilys-entourage-research","tag-gene-editing","tag-gene-therapy","tag-new-cf-research"],"acf":[],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/WordPress-Featured-Image-26.webp","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/27121","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/users\/1719"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/comments?post=27121"}],"version-history":[{"count":5,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/27121\/revisions"}],"predecessor-version":[{"id":27146,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/27121\/revisions\/27146"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media\/27143"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media?parent=27121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/categories?post=27121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/tags?post=27121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}