{"id":27094,"date":"2026-09-03T15:41:52","date_gmt":"2026-09-03T19:41:52","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?p=27094"},"modified":"2026-09-03T16:14:31","modified_gmt":"2026-09-03T20:14:31","slug":"new-emilys-entourage-grant-to-fund-novel-phage-based-therapy-for-drug-resistant-infections-in-cystic-fibrosis","status":"publish","type":"post","link":"https:\/\/www.emilysentourage.org\/tr\/new-emilys-entourage-grant-to-fund-novel-phage-based-therapy-for-drug-resistant-infections-in-cystic-fibrosis\/","title":{"rendered":"Kistik Fibroziste \u0130la\u00e7 Diren\u00e7li Enfeksiyonlar \u0130\u00e7in Yeni Faj Tabanl\u0131 Tedaviyi Finanse Edecek Yeni Emily\u2019s Entourage Hibesi"},"content":{"rendered":"

\u0130nhale bakteriyofaj-antibiyotik kombinasyonu, kal\u0131c\u0131, antibiyoti\u011fe diren\u00e7li akci\u011fer enfeksiyonlar\u0131 i\u00e7in yeni bir tedavi yakla\u015f\u0131m\u0131 sunabilir<\/span><\/i><\/p>\n

\"\"

Emily\u2019s Entourage (EE), California San Diego T\u0131p Fak\u00fcltesi Patoloji ve T\u0131p Profes\u00f6r\u00fc Dr. David T. Pride'a 2026 y\u0131l\u0131ndaki d\u00f6rd\u00fcnc\u00fc Translasyonel Ara\u015ft\u0131rma Hibesini verdi.<\/p><\/div>\n

Lower Merion, PA \u2014 3 Eyl\u00fcl 2026<\/span>Mevcut mutasyon odakl\u0131 tedavilerden yararlanamayan kistik fibrozis (KF) hastalar\u0131 i\u00e7in ara\u015ft\u0131rmalar\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)(3) kurulu\u015fu olan Emily's Entourage (EE), d\u00f6rd\u00fcnc\u00fcs\u00fcn\u00fc gururle duyurur<\/span> 2026 \u00c7eviri Ara\u015ft\u0131rma Hibesi, Kaliforniya \u00dcniversitesi San Diego T\u0131p Fak\u00fcltesi Patoloji ve T\u0131p Profes\u00f6r\u00fc Dr. David T. Pride'a verilmi\u015ftir.<\/span><\/p>\n

Dr. Pride's projesi, standart antimikrobiyal tedavilere diren\u00e7li kistik fibrozis hastalar\u0131ndaki kal\u0131c\u0131 akci\u011fer enfeksiyonlar\u0131n\u0131 tedavi etmek amac\u0131yla, bakterileri \u00f6zellikle hedef al\u0131p \u00f6ld\u00fcren vir\u00fcsler olan bakteriyofajlar\u0131 meropenem antibiyoti\u011fi ile birle\u015ftiren yeni bir solunum yolu tedavisi geli\u015ftirmeyi ama\u00e7lamaktad\u0131r.<\/span><\/p>\n

Kronik enfeksiyonlar ve antibiyotik direncinin geli\u015fimi, KBH'li hastalar i\u00e7in b\u00fcy\u00fck bir tehdit olu\u015fturmakta, hastal\u0131\u011f\u0131n ilerlemesini ve \u00f6l\u00fcm oranlar\u0131n\u0131 tetiklemektedir. Bu enfeksiyonlar aras\u0131nda en zorlu olanlardan biri <\/span>Achromobacter xylosoxidans<\/span><\/i>, tekrarlayan antibiyotik tedavisine ra\u011fmen Kistik Fibrozis (KF) akci\u011ferinde kal\u0131c\u0131 olabilen ve s\u0131kl\u0131kla \u00e7oklu ilaca diren\u00e7li (MDR) veya yayg\u0131n ilaca diren\u00e7li (XDR) profiller geli\u015ftirerek KF hastalar\u0131n\u0131 s\u0131n\u0131rl\u0131 tedavi se\u00e7enekleriyle ba\u015f ba\u015fa b\u0131rakan bir patojen.<\/span><\/p>\n

Dr. Pride ve ekibi, hedef alabilen ve \u00f6ld\u00fcrebilen \u00e7ok say\u0131da ve \u00e7e\u015fitli bir bakteriyofaj koleksiyonu tan\u0131mlad\u0131. <\/span>Achromobacter<\/span><\/i>, geni\u015f bir MDR ve XDR klinik izolat yelpazesinde g\u00f6zlenen aktivite ile. Bu \u00e7al\u0131\u015fmay\u0131 temel alarak \u00f6nemli bir ke\u015fif yapm\u0131\u015flard\u0131r: belirli fajlar meropenem antibiyoti\u011fiyle birle\u015ftirildi\u011finde, ikisi bakterileri yok etmek i\u00e7in sinerjistik olarak \u00e7al\u0131\u015f\u0131r; bu, bakterilerin ba\u015flang\u0131\u00e7ta antibiyoti\u011fe diren\u00e7li oldu\u011fu durumlarda bile ge\u00e7erlidir. Bu bulgu, antibiyotik etkinli\u011finin faj tedavisiyle kombinasyonlar yoluyla yeniden kazan\u0131labilece\u011fi ve diren\u00e7li enfeksiyonlar i\u00e7in tedavi se\u00e7eneklerini geni\u015fletebilece\u011fi yeni bir tedavi yakla\u015f\u0131m\u0131na i\u015faret etmektedir.<\/span><\/p>\n

Ekip, bu yakla\u015f\u0131m\u0131n nas\u0131l ve neden etkili oldu\u011funu daha iyi anlamak i\u00e7in bu sinerjinin temelindeki biyolojik mekanizmalar\u0131 ara\u015ft\u0131racak.<\/span><\/p>\n

\"<\/span>Achromobacter<\/span><\/i> Dr. Pride, \u201dEnfeksiyonlar, birden fazla antibiyoti\u011fe kar\u015f\u0131 diren\u00e7 geli\u015ftirme ve bunu s\u00fcrd\u00fcrme yetenekleri nedeniyle \u00f6zellikle tedavi edilmesi zordur\u201c dedi ve ekledi: \u201dBakteriyofajlar\u0131 mevcut antibiyotiklerle birle\u015ftirerek, antibiyotik aktivitesini yeniden kazand\u0131rma ve konvansiyonel antibiyotik tedavilerini t\u00fcketmi\u015f K\u0130 hastalar\u0131 i\u00e7in yeni bir tedavi se\u00e7ene\u011fi sunma potansiyeline sahibiz.\"<\/span><\/p><\/blockquote>\n

Yakla\u015f\u0131k 10% CF hastas\u0131, mevcut CFTR mod\u00fclat\u00f6rlerinden fayda g\u00f6rmemekte ve s\u0131kl\u0131kla kronik, tedaviye diren\u00e7li enfeksiyonlar\u0131n orant\u0131s\u0131z bir y\u00fck\u00fcyle kar\u015f\u0131 kar\u015f\u0131ya kalmaktad\u0131r. EE, hem CF\u2019nin altta yatan genetik nedenlerini hem de CF ile ya\u015fayanlar\u0131 etkilemeye devam eden ciddi sorunlar\u0131 ele alan ara\u015ft\u0131rmalar\u0131 ilerletmeye kararl\u0131d\u0131r.<\/span><\/p>\n

\u201cEE Ba\u015f Bilim Sorumlusu Do\u00e7. Dr. Chandra Ghose, \u201dBu proje, KF'de antibiyoti\u011fe diren\u00e7li enfeksiyonlarla m\u00fccadele i\u00e7in yenilik\u00e7i ve acilen ihtiya\u00e7 duyulan bir yakla\u015f\u0131m\u0131 temsil ediyor\u201c dedi ve ekledi: \u201dBakteriyofajlar\u0131n diren\u00e7li bakterileri hedef alma konusundaki benzersiz yetene\u011finden yararlanarak ve antimikrobiyal etkilerini yeniden kazand\u0131rmak i\u00e7in bunlar\u0131 mevcut antibiyotiklerle birle\u015ftirerek bu \u00e7al\u0131\u015fma, en zor tedavi edilen enfeksiyonlardan baz\u0131lar\u0131yla kar\u015f\u0131 kar\u015f\u0131ya kalan bireyler i\u00e7in tedavi se\u00e7eneklerini geni\u015fletme potansiyeline sahip.\u201d<\/span><\/p>\n

 <\/p><\/blockquote>\n

Emily's Entourage'\u0131n (EE) Hibe Program\u0131 Hakk\u0131nda<\/b><\/p>\n

Emily's Entourage's (EE) Hibrit Program\u0131, mevcut mutasyon odakl\u0131 tedavilerden yararlanamayan kistik fibrozisli (KF) hastalar i\u00e7in ara\u015ft\u0131rmalar\u0131 ve terap\u00f6tik geli\u015ftirmeyi h\u0131zland\u0131rmak amac\u0131yla finansman sa\u011flamaktad\u0131r. EE; \u00e7eviri hibeleri, i\u015f birli\u011fi hibeleri ve klinik \u00f6ncesi ke\u015fif hibelerinin yan\u0131 s\u0131ra risk sermayesi hay\u0131rseverli\u011fi yat\u0131r\u0131mlar\u0131 dahil olmak \u00fczere \u00e7e\u015fitli finansman mekanizmalar\u0131n\u0131 desteklemektedir.<\/span><\/p>\n

Bug\u00fcne kadar EE, d\u00fcnyan\u0131n d\u00f6rt bir yan\u0131ndan \u00e7ok disiplinli ekibe milyonlarca dolar hibe etmi\u015f ve takip eden fonlarda milyonlarca dolar\u0131n daha g\u00fcvence alt\u0131na al\u0131nmas\u0131na yard\u0131mc\u0131 olmu\u015ftur. Verilen hibeleri incelemek i\u00e7in ziyaret edin <\/span>https:\/\/www.emilysentourage.org\/awarded-grants\/<\/span><\/a>. EE'nin finansman f\u0131rsatlar\u0131 hakk\u0131nda daha fazla bilgi edinmek i\u00e7in \u015fu adresi ziyaret edin <\/span>https:\/\/www.emilysentourage.org\/funding-opportunities\/<\/span><\/a>.<\/span><\/p>\n

Emily'nin \u00c7evresi Hakk\u0131nda<\/b><\/p>\n

Emily\u2019s Entourage (EE), mevcut mutasyon hedefli tedavilerden fayda g\u00f6remeyen kistik fibroz (CF) hastalar\u0131n\u0131n son a\u015famas\u0131ndaki bireyler i\u00e7in yeni tedaviler ve bir \u00e7are bulunmas\u0131na y\u00f6nelik ara\u015ft\u0131rmalar\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3 kurulu\u015fudur. 2011 y\u0131l\u0131ndan bu yana EE, milyonlarca dolarl\u0131k ara\u015ft\u0131rma hibesi vermi\u015f, klinik a\u015famadaki bir CF gen terapisi \u015firketi kurmu\u015f, k\u00fcresel klinik deneme kat\u0131l\u0131m\u0131n\u0131 h\u0131zland\u0131rmak i\u00e7in Clinical Trial Connect (CTC) hasta veritaban\u0131n\u0131 ve klinik deneme e\u015fle\u015ftirme program\u0131n\u0131 geli\u015ftirmi\u015f ve y\u00fcksek etkili ara\u015ft\u0131rma ve ila\u00e7 geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131n\u0131 te\u015fvik etmek i\u00e7in d\u00fcnya \u00e7ap\u0131nda \u00e7aba sarf etmi\u015ftir. Kurulu\u015f, New York Times, STAT, CNN, People ve daha fazlas\u0131 dahil olmak \u00fczere ulusal medyada yer alm\u0131\u015ft\u0131r. Daha fazla bilgi i\u00e7in <\/span>emilysentourage.org<\/span><\/a>.<\/span><\/p>\n

Medya \u0130leti\u015fim<\/b><\/p>\n

Hannah Kleckner<\/span><\/p>\n

Pazarlama ve \u0130leti\u015fim Direkt\u00f6r\u00fc<\/span><\/p>\n

hannah@emilysentourage.org<\/span><\/p>\n



<\/p>","protected":false},"excerpt":{"rendered":"

Solunum yoluyla al\u0131nan bakteri-antibiyotik kombinasyonu, kal\u0131c\u0131 ve antibiyotik direnci olan akci\u011fer enfeksiyonlar\u0131 i\u00e7in yeni bir tedavi yakla\u015f\u0131m\u0131 sunabilir Lower Merion, PA\u20143 Eyl\u00fcl 2026\u2014Kistik fibrozisi (CF) olan ve mevcut mutasyon hedefli tedavilerden yararlanamayan bireyler i\u00e7in ara\u015ft\u0131rma h\u0131zland\u0131ran yenilik\u00e7i 501(c)(3) organizasyonu Emily\u2019s Entourage (EE), David T.'ye 2026 y\u0131l\u0131na ait d\u00f6rd\u00fcnc\u00fc Translational Research Grant'\u0131n\u0131 vermekten gurur duyuyor.... <\/p>\n

<\/div>\n

Daha fazla bilgi edinin<\/a><\/p>","protected":false},"author":1719,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"New Emily\u2019s Entourage Grant to Fund Novel Phage-Based Therapy for Drug-Resistant Infections in Cystic Fibrosis","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[178],"tags":[197,217,223,204,270,189],"class_list":["post-27094","post","type-post","status-publish","format-standard","hentry","category-press-releases","tag-cf-research","tag-cf-science","tag-ee-grant","tag-ee-research","tag-new-cf-research","tag-phage-therapy"],"acf":[],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/27094","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/users\/1719"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/comments?post=27094"}],"version-history":[{"count":5,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/27094\/revisions"}],"predecessor-version":[{"id":27100,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/27094\/revisions\/27100"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media?parent=27094"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/categories?post=27094"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/tags?post=27094"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}