{"id":25531,"date":"2025-08-05T12:56:00","date_gmt":"2025-08-05T16:56:00","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?p=25531"},"modified":"2025-10-16T09:01:32","modified_gmt":"2025-10-16T13:01:32","slug":"advancing-cf-science-emilys-entourage-announces-new-2025-research-grants","status":"publish","type":"post","link":"https:\/\/www.emilysentourage.org\/tr\/advancing-cf-science-emilys-entourage-announces-new-2025-research-grants\/","title":{"rendered":"KF Biliminde \u0130lerleme: Emily's Entourage Yeni 2025 Ara\u015ft\u0131rma Hibelerini A\u00e7\u0131klad\u0131"},"content":{"rendered":"

EE, Son 10% i\u00e7in \u0130novasyonu Destekleyecek Ara\u015ft\u0131rma Hibelerini \u00d6d\u00fcllendirdi<\/strong><\/h3>\n

Emily's Entourage duyurmaktan gurur duyar Translasyonel Ara\u015ft\u0131rma Hibelerimizin 2025 y\u0131l\u0131 al\u0131c\u0131lar\u0131<\/strong>-Tek bir hedefe y\u00f6nelik d\u00f6rt heyecan verici proje: Kistik fibrozis (KF) toplulu\u011funun son 10%'sinde yer alan ve hala at\u0131l\u0131m bekleyenler i\u00e7in hayat kurtar\u0131c\u0131 ara\u015ft\u0131rma ve ila\u00e7 geli\u015ftirmeyi h\u0131zland\u0131rmak.<\/p>\n

Son geli\u015fmeler KF toplulu\u011funun 90%'si i\u00e7in gelece\u011fi yeniden \u015fekillendirmi\u015ftir; ancak d\u0131\u015far\u0131da kalan 10% i\u00e7in bu gelecek hala ula\u015f\u0131lamaz durumdad\u0131r. Bu hibeler bunu de\u011fi\u015ftirmekle ilgili. Stat\u00fckoyu kabullenmeyi reddetmek, daha h\u0131zl\u0131 ilerleyen ve daha uza\u011fa ula\u015fan umut verici bilime yat\u0131r\u0131m yapmak ve geride kalanlar i\u00e7in gidi\u015fat\u0131 de\u011fi\u015ftirmekle ilgilidir.<\/p>\n

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\"\"\"Mevcut CFTR mod\u00fclat\u00f6rlerine yan\u0131t vermeyen mutasyonlar i\u00e7in tedavi sa\u011flayabilecek gen d\u00fczenleme teknolojilerinden, KF'li ki\u015filerde hastal\u0131\u011f\u0131n ilerlemesine ve \u00f6l\u00fcmlere yol a\u00e7abilen \u00e7oklu ilaca diren\u00e7li bakteriler i\u00e7in faj tedavilerinin geli\u015ftirilmesine kadar, Bu hibeler EE'nin portf\u00f6y\u00fcn\u00fc derinle\u015ftiriyor ve bizi KF'li t\u00fcm insanlar i\u00e7in hayat kurtar\u0131c\u0131 tedavilere yakla\u015ft\u0131r\u0131yor<\/strong>.\"<\/em><\/p>\n

- <\/em><\/strong>Chandra Ghose, PhD, <\/em><\/strong>Ba\u015f Bilim Sorumlusu<\/em><\/p>\n

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\"\"Nadir KF Mutasyonlar\u0131 i\u00e7in Gen D\u00fczenleme Stratejilerinin H\u0131zland\u0131r\u0131lmas\u0131\u00a0<\/strong><\/h3>\n

David R. Liu, PhD | MIT ve Harvard Broad Enstit\u00fcs\u00fc<\/em><\/p>\n

Bu proje, geli\u015fmi\u015f asal d\u00fczenleme ve hesaplamal\u0131 modelleme kullanarak, mutasyon hedefli tedavilerden yoksun olan KF hastalar\u0131 i\u00e7in h\u0131zla ki\u015fiselle\u015ftirilmi\u015f gen d\u00fczenleme tedavileri geli\u015ftirmeyi ama\u00e7lamaktad\u0131r.<\/p>\n

Daha fazla oku >>><\/a><\/strong><\/em><\/h4>\n

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\"\"<\/strong>\u0130laca Diren\u00e7li Enfeksiyonlara Kar\u015f\u0131 M\u00fccadele<\/strong><\/h3>\n

Anca Segall, PhD | San Diego Eyalet \u00dcniversitesi<\/em><\/p>\n

Bu proje, ilaca diren\u00e7li hastal\u0131klarla m\u00fccadele etmek i\u00e7in faj-antibiyotik kombinasyonlar\u0131n\u0131 ara\u015ft\u0131rmaktad\u0131r. Achromobacter<\/em> tedavisi en zor enfeksiyonlardan baz\u0131lar\u0131yla kar\u015f\u0131 kar\u015f\u0131ya olanlar i\u00e7in tedavi etkinli\u011fini yeniden sa\u011flamay\u0131 ve se\u00e7enekleri geni\u015fletmeyi ama\u00e7lamaktad\u0131r.<\/p>\n

Daha fazla oku >>><\/a><\/strong><\/em><\/h4>\n

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\"\"Hassas Okuma Terapisi ile Anlams\u0131z Mutasyonlar\u0131n Hedeflenmesi<\/strong><\/h3>\n

Andrei Korostelev, PhD | UMass Chan T\u0131p Fak\u00fcltesi<\/em><\/p>\n

CFTR mRNA's\u0131ndaki erken durma sinyallerini atlamak i\u00e7in readthrough antisense oligon\u00fckleotidleri (R-ASO'lar) kullanan bu ara\u015ft\u0131rma, i\u015flevsel protein \u00fcretimini geri kazanmay\u0131 ve KF'nin nonsense mutasyonlar\u0131na sahip olanlar i\u00e7in hedefli tedavilerin kilidini a\u00e7may\u0131 ama\u00e7lamaktad\u0131r.<\/p>\n

Daha fazla oku >>><\/a><\/strong><\/em><\/h4>\n

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\"\"Hatal\u0131 CFTR Gen Segmentlerinin Retron Edit\u00f6rleri ile De\u011fi\u015ftirilmesi<\/strong><\/h3>\n

Ilya Finkelstein, PhD | Austin'deki Teksas \u00dcniversitesi<\/em><\/p>\n

Bu \u00e7al\u0131\u015fma, hatal\u0131 CFTR gen segmentlerini yeniden yazmak i\u00e7in retron d\u00fczenleyicileri geli\u015ftirerek, mevcut CFTR mod\u00fclat\u00f6r tedavilerinden fayda g\u00f6rmeyen KF'li bireyler i\u00e7in kal\u0131c\u0131 tedaviler sunmay\u0131 ama\u00e7layan tek bedene uyan bir\u00e7ok gen d\u00fczenleme yakla\u015f\u0131m\u0131n\u0131n temelini atmaktad\u0131r.<\/p>\n

Daha fazla oku >>><\/strong><\/em><\/a><\/h4>\n

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Bu d\u00f6rt hibe, Emily's Entourage'\u0131n \u00f6nc\u00fc ara\u015ft\u0131rma hibe program\u0131 \u00fczerine in\u015fa edilmi\u015ftir. Emily's Entourage 2011 y\u0131l\u0131ndan bu yana 42 hibe verildi<\/strong> alt\u0131 \u00fclkeden gelen ara\u015ft\u0131rmac\u0131lara $52.3 milyon ek fon sa\u011flanm\u0131\u015ft\u0131r.<\/strong> \u00e7e\u015fitli terap\u00f6tik yakla\u015f\u0131mlar aras\u0131nda.<\/p>\n

H\u00e2l\u00e2 bekleyenler i\u00e7in bu bir ara\u015ft\u0131rmadan daha fazlas\u0131d\u0131r. Bu ileriye do\u011fru bir hareket.Ger\u00e7ek \u00e7\u00f6z\u00fcmlere ve KF'siz bir gelece\u011fe do\u011fru ivme.<\/strong><\/p>\n

Bu kadar \u00e7abuk gelmesi m\u00fcmk\u00fcn de\u011fil.<\/p>\n

Emily's Entourage hakk\u0131nda daha fazla bilgi edinin \u00f6d\u00fcll\u00fc hibeler<\/a> ve mevcut fon olanaklari<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"

EE Awards Research Grants to Fuel Innovation for the Final 10% Emily\u2019s Entourage is proud to announce the 2025 recipients of our Translational Research Grants\u2014four exciting projects driven by one goal: accelerating lifesaving research and drug development for those in the final 10% of the cystic fibrosis (CF) community who are still waiting for their… <\/p>\n

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Daha fazla bilgi edinin<\/a><\/p>","protected":false},"author":1719,"featured_media":25580,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"%%post_title%%","_seopress_titles_desc":"%%post_excerpt%%","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"none","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[73,197,217,7,208,230,232,231],"class_list":["post-25531","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-cf","tag-cf-research","tag-cf-science","tag-cystic-fibrosis","tag-cystic-fibrosis-research","tag-cystic-fibrosis-science","tag-final-10","tag-new-therapies-for-cf"],"acf":[],"jetpack_featured_media_url":"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/WordPress-Featured-Image-2.png","jetpack_sharing_enabled":true,"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/25531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/users\/1719"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/comments?post=25531"}],"version-history":[{"count":5,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/25531\/revisions"}],"predecessor-version":[{"id":25862,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/25531\/revisions\/25862"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media\/25580"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media?parent=25531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/categories?post=25531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/tags?post=25531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}