{"id":25404,"date":"2025-07-09T09:00:29","date_gmt":"2025-07-09T13:00:29","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?p=25404"},"modified":"2025-07-09T08:47:42","modified_gmt":"2025-07-09T12:47:42","slug":"new-emilys-entourage-research-grant-to-advance-phage-therapy-for-drug-resistant-cystic-fibrosis-infections","status":"publish","type":"post","link":"https:\/\/www.emilysentourage.org\/tr\/new-emilys-entourage-research-grant-to-advance-phage-therapy-for-drug-resistant-cystic-fibrosis-infections\/","title":{"rendered":"Yeni Emily's Entourage Ara\u015ft\u0131rma Bursu \u0130laca Diren\u00e7li Kistik Fibroz Enfeksiyonlar\u0131 i\u00e7in Faj Tedavisini Geli\u015ftirecek"},"content":{"rendered":"

Yeni finanse edilen San Diego Eyalet \u00dcniversitesi projesi, KF'li bireylerde hastal\u0131\u011f\u0131n ilerlemesine neden olan, tedavisi zor KF patojenleri i\u00e7in yeni bakteriyofaj-antibiyotik tedavilerini optimize etmeyi ama\u00e7l\u0131yor.\u00a0<\/span><\/i><\/p>\n

\"\"

Anca Segall, PhD'nin \u00f6nc\u00fc \u00e7al\u0131\u015fmas\u0131, KF'deki en tehlikeli ve az \u00e7al\u0131\u015f\u0131lm\u0131\u015f patojenlerden biri olan \u00e7ok ilaca diren\u00e7li Achromobacter enfeksiyonlar\u0131 i\u00e7in faj tedavisini optimize ediyor.<\/p><\/div>\n

Lower Merion, PA-9 Temmuz 2025<\/b>-Mevcut CFTR mod\u00fclat\u00f6r tedavilerinden faydalanamayan kistik fibrozisli (KF) bireyler i\u00e7in ara\u015ft\u0131rmalar\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)(3) kurulu\u015f olan Emily's Entourage (EE), San Diego Eyalet \u00dcniversitesi'nde biyoloji profes\u00f6r\u00fc olan PhD Anca Segall'a yeni bir 2025 ara\u015ft\u0131rma hibe \u00f6d\u00fcl\u00fc verdi\u011fini duyurdu. Bu fon, Dr. Segall'\u0131n \u00e7oklu ilaca diren\u00e7li KF hastalar\u0131na y\u00f6nelik faj tedavisini optimize eden \u00f6nc\u00fc \u00e7al\u0131\u015fmalar\u0131n\u0131 desteklemektedir. <\/span>Achromobacter<\/span><\/i> enfeksiyonlar\u0131 - KF'deki en tehlikeli ve yeterince \u00e7al\u0131\u015f\u0131lmam\u0131\u015f patojenlerden biri.<\/span><\/p>\n

Zararl\u0131 bakterileri hedef almak i\u00e7in bakteriyofaj olarak bilinen bakteriyel vir\u00fcsleri kullanan faj terapisi (PT), antibiyoti\u011fe diren\u00e7li enfeksiyonlar\u0131n tedavisinde son \u00e7are se\u00e7ene\u011fi olarak h\u0131zla ilgi g\u00f6rmektedir. EE taraf\u0131ndan finanse edilen \"Terapi Hedeflemesi i\u00e7in Faj Kokteyllerinin Optimize Edilmesi\" ba\u015fl\u0131kl\u0131 bu yeni proje sayesinde <\/span>Achromobacter<\/span><\/i>Dr. Segall'\u0131n ekibi, fajlar ve antibiyotiklerin en iyi kombinasyonlar\u0131n\u0131 belirlemeye \u00e7al\u0131\u015facak. <\/span>Achromobacter<\/span><\/i>\u00c7o\u011fu antibiyoti\u011fe diren\u00e7li olan ve KF'li ki\u015filerde sa\u011fl\u0131\u011f\u0131n bozulmas\u0131yla ba\u011flant\u0131l\u0131 olan bir patojen.\u00a0<\/span><\/p>\n

Proje, bakterilerin fajlara kar\u015f\u0131 nas\u0131l diren\u00e7 geli\u015ftirdi\u011fini ve bu diren\u00e7 de\u011fi\u015fikliklerinin antibiyotik duyarl\u0131l\u0131\u011f\u0131n\u0131 nas\u0131l etkiledi\u011fini haritaland\u0131rarak, yaln\u0131zca bakterileri \u00f6ld\u00fcrmekle kalmay\u0131p potansiyel olarak onlar\u0131 antibiyotiklere kar\u015f\u0131 yeniden duyarl\u0131 hale getiren ve zaman i\u00e7inde zindeliklerini azaltan daha ak\u0131ll\u0131, daha etkili tedaviler tasarlamay\u0131 ama\u00e7l\u0131yor.<\/span><\/p>\n

Dr. Segall, \"Halihaz\u0131rda mevcut olan CFTR mod\u00fclat\u00f6rlerinin dikkate de\u011fer etkisine ra\u011fmen, KF toplulu\u011funun yakla\u015f\u0131k 10%'si uygulanabilir tedavi se\u00e7eneklerinden yoksundur\" dedi. \"Bu ki\u015filer \u00f6zellikle a\u015fa\u011f\u0131daki gibi patojenlerden kaynaklanan \u00f6l\u00fcmc\u00fcl enfeksiyonlara kar\u015f\u0131 savunmas\u0131zd\u0131r <\/span>Achromobacter<\/span><\/i>Bu hastal\u0131k i\u00e7in neredeyse hi\u00e7 hedefe y\u00f6nelik ara\u015ft\u0131rma program\u0131 ve FDA onayl\u0131 \u00e7ok az tedavi bulunmaktad\u0131r. Emily's Entourage'\u0131n deste\u011fi, tedavi i\u00e7in acilen ihtiya\u00e7 duyulan ara\u00e7lar\u0131 geli\u015ftirmemize yard\u0131mc\u0131 olmak a\u00e7\u0131s\u0131ndan hayati \u00f6nem ta\u015f\u0131maktad\u0131r. <\/span>Achromobacter<\/span><\/i> KF pop\u00fclasyonunda.\"<\/span><\/p>\n

Belirli fajlar\u0131n nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 ve nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 karakterize etmenin yan\u0131 s\u0131ra <\/span>Achromobacter<\/span><\/i> Dr. Segall'\u0131n ekibi, gelecekteki tedavi stratejilerini geli\u015ftirmek ve faj ile antibiyotik kombinasyonlar\u0131 aras\u0131ndaki sinerjileri belirlemek i\u00e7in \u00f6nceki faj tedavisi vakalar\u0131ndan klinik \u00f6rnekleri ve metagenomik verileri kullanacak. Projenin bulgular\u0131 ki\u015fiselle\u015ftirilmi\u015f, hassas tedaviler hakk\u0131nda bilgi verebilir ve d\u00fcnya \u00e7ap\u0131nda KF klinisyenleri ve ara\u015ft\u0131rmac\u0131lar\u0131yla payla\u015f\u0131labilir.<\/span><\/p>\n

EE'nin Bilimsel Ba\u015f Sorumlusu PhD Chandra Ghose, \"EE, hala bir at\u0131l\u0131m bekleyen 10% KF'li insana ula\u015fmak i\u00e7in en umut verici, y\u00fcksek etkili bilimi finanse etmeye derinden kararl\u0131d\u0131r\" dedi. \"Bu proje, kritik bo\u015fluklar\u0131 dolduran ve hayat de\u011fi\u015ftiren tedavileri h\u0131zla eri\u015filebilir hale getiren cesur, yenilik\u00e7i ara\u015ft\u0131rmalar\u0131 h\u0131zland\u0131rma misyonumuzu \u00f6rneklemektedir.\"<\/span><\/p>\n

Emily's Entourage'\u0131n (EE) Hibe Program\u0131 Hakk\u0131nda\u00a0<\/b><\/p>\n

Emily's Entourage'\u0131n (EE) Hibe Program\u0131, mevcut mutasyon hedefli tedavilerden faydalanamayan kistik fibrozis (KF) hastalar\u0131 i\u00e7in ara\u015ft\u0131rma ve terap\u00f6tik geli\u015ftirmeyi h\u0131zland\u0131rmak amac\u0131yla hibe fonu sa\u011flamaktad\u0131r. EE, \u00e7eviri hibeleri, i\u015fbirli\u011fine dayal\u0131 hibeler ve klinik \u00f6ncesi ke\u015fif hibeleri dahil olmak \u00fczere \u00e7e\u015fitli hibe finansman mekanizmalar\u0131n\u0131n yan\u0131 s\u0131ra giri\u015fimci hay\u0131rseverlik yat\u0131r\u0131mlar\u0131 yoluyla da finansman sa\u011flamaktad\u0131r.<\/span><\/p>\n

EE bug\u00fcne kadar d\u00fcnyan\u0131n d\u00f6rt bir yan\u0131ndaki \u00e7ok disiplinli ekiplere milyonlarca dolar hibe vermi\u015f ve milyonlarca dolarl\u0131k devam finansman\u0131n\u0131n sa\u011flanmas\u0131na yard\u0131mc\u0131 olmu\u015ftur. Verilen hibeleri g\u00f6r\u00fcnt\u00fclemek i\u00e7in \u015fu adresi ziyaret edin <\/span>https:\/\/www.emilysentourage.org\/awarded-grants\/<\/span><\/a>. <\/span><\/p>\n

EE'nin finansman f\u0131rsatlar\u0131 hakk\u0131nda daha fazla bilgi edinmek i\u00e7in \u015fu adresi ziyaret edin <\/span>https:\/\/www.emilysentourage.org\/funding-opportunities\/<\/span><\/a>.\u00a0<\/span><\/p>\n

Emily'nin \u00c7evresi Hakk\u0131nda<\/b><\/p>\n

Emily's Entourage, mevcut mutasyon hedefli tedavilerden faydalanamayan kistik fibrozis (KF) pop\u00fclasyonunun son 10%'sindeki bireyler i\u00e7in yeni tedaviler ve bir tedavi ara\u015ft\u0131rmas\u0131n\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3't\u00fcr. Emily's Entourage 2011 y\u0131l\u0131ndan bu yana milyonlarca dolarl\u0131k ara\u015ft\u0131rma hibesi vermi\u015f, \u015fu anda klinik a\u015famada olan bir KF gen terapisi \u015firketi kurmu\u015f, klinik deneylere kat\u0131l\u0131m\u0131 h\u0131zland\u0131rmak i\u00e7in Clinical Trial Connect (CTC) hasta veri taban\u0131n\u0131 ve klinik deney e\u015fle\u015ftirme program\u0131n\u0131 geli\u015ftirmi\u015f ve d\u00fcnya \u00e7ap\u0131nda y\u00fcksek etkili ara\u015ft\u0131rma ve ila\u00e7 geli\u015ftirme \u00e7abalar\u0131na \u00f6nc\u00fcl\u00fck etmi\u015ftir. Kurulu\u015f, New York Times, STAT, CNN, People ve daha fazlas\u0131 dahil olmak \u00fczere ulusal medyada yer alm\u0131\u015ft\u0131r. Daha fazla bilgi i\u00e7in <\/span>emilysentourage.org<\/span><\/a>.<\/span><\/p>\n

Medya \u0130leti\u015fim<\/b><\/p>\n

Hannah Kleckner<\/span><\/p>\n

Pazarlama ve \u0130leti\u015fim Direkt\u00f6r\u00fc<\/span><\/p>\n

hannah@emilysentourage.org<\/span><\/p>\n



<\/p>","protected":false},"excerpt":{"rendered":"

Newly-funded San Diego State University project aims to optimize novel bacteriophage-antibiotic treatments for hard-to-treat CF pathogens, which drive disease progression in individuals with CF.\u00a0 Lower Merion, PA\u2014July 9, 2025\u2014Emily\u2019s Entourage (EE), an innovative 501(c)(3) organization accelerating research for individuals with cystic fibrosis (CF) who do not benefit from existing CFTR modulator therapies, has announced a… <\/p>\n

<\/div>\n

Daha fazla bilgi edinin<\/a><\/p>","protected":false},"author":1719,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"%%post_title%%","_seopress_titles_desc":"%%post_excerpt%%","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"none","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[178],"tags":[197,208,216,91,189],"class_list":["post-25404","post","type-post","status-publish","format-standard","hentry","category-press-releases","tag-cf-research","tag-cystic-fibrosis-research","tag-ee-grants","tag-grants","tag-phage-therapy"],"acf":[],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/25404","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/users\/1719"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/comments?post=25404"}],"version-history":[{"count":5,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/25404\/revisions"}],"predecessor-version":[{"id":25412,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/25404\/revisions\/25412"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media?parent=25404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/categories?post=25404"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/tags?post=25404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}