{"id":21102,"date":"2024-06-13T09:00:19","date_gmt":"2024-06-13T13:00:19","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?p=21102"},"modified":"2024-06-13T09:11:48","modified_gmt":"2024-06-13T13:11:48","slug":"emilys-entourage-awards-1487500-research-grant-to-launch-pioneering-phage-clinical-trial-for-combatting-cf-infections","status":"publish","type":"post","link":"https:\/\/www.emilysentourage.org\/tr\/emilys-entourage-awards-1487500-research-grant-to-launch-pioneering-phage-clinical-trial-for-combatting-cf-infections\/","title":{"rendered":"Emily's Entourage, KF Enfeksiyonlar\u0131yla M\u00fccadelede \u00d6nc\u00fc Faj Klinik Denemesini Ba\u015flatmak i\u00e7in $1,487,500 Ara\u015ft\u0131rma Hibesi Verdi"},"content":{"rendered":"

Kaliforniya \u00dcniversitesi, San Diego ve Pittsburgh \u00dcniversitesi'ndeki ara\u015ft\u0131rma ekipleri taraf\u0131ndan y\u00fcr\u00fct\u00fclen ve finanse edilen proje, faj tedavisini klinik uygulamaya ta\u015f\u0131may\u0131 ve kistik fibrozda yayg\u0131n olarak g\u00f6r\u00fclen antibiyoti\u011fe diren\u00e7li patojenlerle m\u00fccadele etmek i\u00e7in klinik \u00e7al\u0131\u015fmalar\u0131 standartla\u015ft\u0131rmay\u0131 ama\u00e7l\u0131yor.<\/i><\/p>\n

\"\"

Yukar\u0131dan A\u015fa\u011f\u0131ya: David Pride, MD, PhD; Douglas Conrad, MD; Daria Van Tyne, PhD.<\/p><\/div>\n

Lower Merion, PA - 13 Haziran 2024 -<\/strong> Kistik fibrozis (KF) hastalar\u0131n\u0131n son 10%'si i\u00e7in yeni tedaviler ve tedavi ara\u015ft\u0131rmalar\u0131n\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3 kurulu\u015fu olan Emily's Entourage (EE), bug\u00fcn Kaliforniya \u00dcniversitesi, San Diego'da (UCSD) patoloji ve t\u0131p profes\u00f6r\u00fc olan David Pride, MD, PhD'ye $1,487,500 \u0130\u015fbirli\u011fi Hibe fonu verdi\u011fini duyurdu; T\u0131p profes\u00f6r\u00fc ve UCSD Yeti\u015fkin Kistik Fibrozis Klini\u011fi direkt\u00f6r\u00fc Douglas Conrad ve Pittsburgh \u00dcniversitesi T\u0131p Fak\u00fcltesi'nde t\u0131p profes\u00f6r\u00fc yard\u0131mc\u0131s\u0131 Daria Van Tyne.<\/p>\n

Bu fon, KF'li ki\u015filerde yayg\u0131n olan antibiyoti\u011fe diren\u00e7li patojenlerle m\u00fccadele etmek i\u00e7in bakteriyofajlar\u0131n (fajlar) - belirli bakterileri se\u00e7ici olarak hedefleyip yok edebilen vir\u00fcsler - geli\u015ftirilmesi ve uygulanmas\u0131nda \u00f6nc\u00fc ara\u015ft\u0131rmalara \u00f6nc\u00fcl\u00fck edecektir.<\/p>\n

KF, s\u0131k ve kronik kullan\u0131m nedeniyle geleneksel antibiyotik tedavisine genellikle diren\u00e7li hale gelen tekrarlayan solunum yolu enfeksiyonlar\u0131 ile karakterizedir. \"KF tedavisinde antibiyotik kullan\u0131m\u0131n\u0131 azalt\u0131rken faj tedavisini kolayla\u015ft\u0131rmak i\u00e7in faj teknolojilerinden yararlanmak\" ba\u015fl\u0131kl\u0131 \u00f6d\u00fcll\u00fc proje, faj tedavisinden etkili bir \u015fekilde yararlanmak i\u00e7in \u00e7ok y\u00f6nl\u00fc bir strateji ile bu kritik ihtiyac\u0131 ele almaktad\u0131r.<\/p>\n

Dr. David Pride liderli\u011findeki bu yenilik\u00e7i proje, UCSD ve Pittsburgh \u00dcniversitesi'nden ekiplerle birlikte, mevcut faj koleksiyonlar\u0131n\u0131 geni\u015fleterek, faj konak aral\u0131klar\u0131n\u0131 geli\u015ftirerek ve KF patojenleriyle m\u00fccadele i\u00e7in antibiyotik-faj kombinasyon rejimlerini de\u011ferlendirerek sa\u011flam bir terap\u00f6tik cephanelik olu\u015fturmay\u0131 ama\u00e7l\u0131yor.<\/p>\n

Heyecan verici bir \u015fekilde, bu proje ayn\u0131 zamanda KF'li ki\u015filerde antibiyoti\u011fe diren\u00e7li enfeksiyonlarla m\u00fccadele etmek i\u00e7in yeni, alternatif yakla\u015f\u0131mlar\u0131n geli\u015ftirilmesinde \u00f6nemli bir kilometre ta\u015f\u0131n\u0131 i\u015faret ederek faj tedavisini klini\u011fe ta\u015f\u0131yacakt\u0131r. \u00c7al\u0131\u015fma, birden fazla kurumdaki klinik deneyleri standartla\u015ft\u0131rarak tutarl\u0131 uygulama y\u00f6ntemleri ve kar\u015f\u0131la\u015ft\u0131r\u0131labilir sonu\u00e7lar elde etmeye \u00e7al\u0131\u015f\u0131yor. Bu ileriye d\u00f6n\u00fck yakla\u015f\u0131m, daha g\u00fcvenilir ve uygulanabilir sonu\u00e7lara yol a\u00e7arak KF tedavisinde \u00f6nemli ilerlemelerin \u00f6n\u00fcn\u00fc a\u00e7abilir.<\/p>\n

Emily's Entourage'\u0131n ba\u015f bilimsel sorumlusu Chandra Ghose, \"Bu \u00e7\u0131\u011f\u0131r a\u00e7an \u00e7abada Dr. Pride ve ekibini desteklemekten heyecan duyuyoruz\" dedi. \"Onlar\u0131n yenilik\u00e7i yakla\u015f\u0131m\u0131, KF'li ki\u015filerde antibiyoti\u011fe diren\u00e7li enfeksiyonlar\u0131n s\u00fcregelen sorununu ele alma konusunda b\u00fcy\u00fck umut vaat ediyor. Diren\u00e7li enfeksiyonlar hastal\u0131\u011f\u0131n ilerlemesini ve \u00f6l\u00fcm oran\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rd\u0131\u011f\u0131ndan, bunlarla m\u00fccadele etmek i\u00e7in daha etkili yollar geli\u015ftirmek, \u00f6zellikle CFTR mod\u00fclat\u00f6rleri olmayan son 10% i\u00e7in ya\u015famlar\u0131 iyile\u015ftirmek ve uzatmak i\u00e7in gereklidir. Bu proje, KF ile ya\u015fayan bireyler i\u00e7in d\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc tedaviler geli\u015ftirme taahh\u00fcd\u00fcm\u00fcz\u00fc somutla\u015ft\u0131rmaktad\u0131r.\"<\/p>\n

Dr. Pride, \"Geleneksel tedavilerin s\u0131n\u0131rlamalar\u0131n\u0131n \u00fcstesinden gelen faj terapisi, g\u00fcvenli ve hedefe y\u00f6nelik bir alternatif sunarak antibiyotik direncini potansiyel olarak en aza indirirken hasta sonu\u00e7lar\u0131n\u0131 da iyile\u015ftiriyor\" dedi. \"Bu proje, faj koleksiyonlar\u0131n\u0131 g\u00fc\u00e7lendirerek ve da\u011f\u0131t\u0131m mekanizmalar\u0131n\u0131 geli\u015ftirerek, KF patojenlerine kar\u015f\u0131 sa\u011flam bir cephanelik olu\u015fturmay\u0131 ve k\u00fcresel olarak geli\u015fmi\u015f hasta bak\u0131m\u0131n\u0131n \u00f6n\u00fcn\u00fc a\u00e7may\u0131 ama\u00e7l\u0131yor. Bu \u00f6nemli ara\u015ft\u0131rmay\u0131 ilerletmeye odaklan\u0131rken bize verdikleri destek i\u00e7in Emily's Entourage'a minnettar\u0131z.\"<\/p>\n

EE, KF pop\u00fclasyonunun son 10%'si i\u00e7in h\u0131zland\u0131r\u0131lm\u0131\u015f, d\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc tedavilere yol a\u00e7an ve kimsenin geride kalmamas\u0131n\u0131 sa\u011flayan en ileri ara\u015ft\u0131rmalar\u0131 desteklemeye kararl\u0131d\u0131r.<\/p>\n

Emily's Entourage'\u0131n (EE) Hibe Program\u0131 Hakk\u0131nda\u00a0<\/b><\/p>\n

Emily's Entourage'\u0131n (EE) Hibe Program\u0131, mevcut mutasyon hedefli tedavilerden faydalanamayan kistik fibrozis (KF) hastalar\u0131 i\u00e7in ara\u015ft\u0131rma ve terap\u00f6tik geli\u015ftirmeyi h\u0131zland\u0131rmak amac\u0131yla hibe fonu sa\u011flamaktad\u0131r. EE, \u00e7eviri hibeleri, i\u015fbirli\u011fine dayal\u0131 hibeler ve klinik \u00f6ncesi ke\u015fif hibeleri dahil olmak \u00fczere \u00e7e\u015fitli hibe finansman mekanizmalar\u0131n\u0131n yan\u0131 s\u0131ra giri\u015fimci hay\u0131rseverlik yat\u0131r\u0131mlar\u0131 yoluyla da finansman sa\u011flamaktad\u0131r.<\/p>\n

EE bug\u00fcne kadar d\u00fcnyan\u0131n d\u00f6rt bir yan\u0131ndaki \u00e7ok disiplinli ekiplere milyonlarca dolar hibe vermi\u015f ve milyonlarca dolarl\u0131k devam finansman\u0131n\u0131n sa\u011flanmas\u0131na yard\u0131mc\u0131 olmu\u015ftur. Verilen hibeleri g\u00f6r\u00fcnt\u00fclemek i\u00e7in \u015fu adresi ziyaret edin https:\/\/www.emilysentourage.org\/awarded-grants\/<\/a>. EE'nin finansman f\u0131rsatlar\u0131 hakk\u0131nda daha fazla bilgi edinmek i\u00e7in \u015fu adresi ziyaret edin https:\/\/www.emilysentourage.org\/funding-opportunities\/<\/a>.<\/p>\n

Emily'nin \u00c7evresi Hakk\u0131nda<\/b><\/p>\n

Emily's Entourage, mevcut mutasyon hedefli tedavilerden yararlanamayan kistik fibrozis (KF) pop\u00fclasyonunun son 10%'sindeki bireyler i\u00e7in yeni tedaviler ve bir tedavi i\u00e7in ara\u015ft\u0131rmalar\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3't\u00fcr. Emily's Entourage 2011 y\u0131l\u0131ndan bu yana milyonlarca dolarl\u0131k ara\u015ft\u0131rma hibesi vermi\u015f, \u015fu anda sat\u0131n al\u0131nan bir KF gen terapisi \u015firketini kurmu\u015f, klinik deneylere kat\u0131l\u0131m\u0131 h\u0131zland\u0131rmak i\u00e7in bir hasta kay\u0131t defteri ve klinik deney e\u015fle\u015ftirme program\u0131 geli\u015ftirmi\u015f ve y\u00fcksek etkili ara\u015ft\u0131rma ve ila\u00e7 geli\u015ftirmeye y\u00f6nelik d\u00fcnya \u00e7ap\u0131nda \u00e7abalara \u00f6nc\u00fcl\u00fck etmi\u015ftir. Kurulu\u015f, New York Times, STAT, CNN, People ve daha fazlas\u0131 dahil olmak \u00fczere ulusal medyada yer alm\u0131\u015ft\u0131r. Daha fazla bilgi i\u00e7in emilysentourage.org<\/a>.<\/p>\n

\u00a0<\/i><\/p>\n

Medya \u0130leti\u015fim<\/b><\/p>\n

Hannah Kleckner<\/p>\n

Pazarlama ve \u0130leti\u015fim Direkt\u00f6r\u00fc<\/p>\n

hannah@emilysentourage.org<\/a><\/p>\n

\u00a0<\/i><\/p>","protected":false},"excerpt":{"rendered":"

Kaliforniya \u00dcniversitesi, San Diego ve Pittsburgh \u00dcniversitesi ara\u015ft\u0131rma ekipleri taraf\u0131ndan y\u00fcr\u00fct\u00fclen ve finanse edilen proje, faj terapisini klinik uygulamaya ta\u015f\u0131may\u0131 ve kistik fibrozda yayg\u0131n olarak g\u00f6r\u00fclen antibiyoti\u011fe diren\u00e7li patojenlerle m\u00fccadele etmek i\u00e7in klinik \u00e7al\u0131\u015fmalar\u0131 standartla\u015ft\u0131rmay\u0131 ama\u00e7l\u0131yor. Lower Merion, PA - 13 Haziran 2024 - Emily's Entourage (EE), kistik fibroz i\u00e7in ara\u015ft\u0131rmalar\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3... <\/p>\n

<\/div>\n

Daha fazla bilgi edinin<\/a><\/p>","protected":false},"author":1719,"featured_media":21112,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"none","_seopress_titles_title":"%%post_title%%","_seopress_titles_desc":"%%post_excerpt%%","_seopress_robots_index":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[178],"tags":[7,188,78,89,189,111],"class_list":["post-21102","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-releases","tag-cystic-fibrosis","tag-gene-therapy","tag-nonsense-mutations","tag-phage","tag-phage-therapy","tag-research"],"acf":[],"jetpack_featured_media_url":"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Pride-Release-FI.png","jetpack_sharing_enabled":true,"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/21102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/users\/1719"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/comments?post=21102"}],"version-history":[{"count":5,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/21102\/revisions"}],"predecessor-version":[{"id":21131,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/21102\/revisions\/21131"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media\/21112"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media?parent=21102"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/categories?post=21102"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/tags?post=21102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}