{"id":20016,"date":"2023-11-21T09:46:57","date_gmt":"2023-11-21T14:46:57","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?p=20016"},"modified":"2023-12-20T05:15:32","modified_gmt":"2023-12-20T10:15:32","slug":"emilys-entourage-awards-220000-research-grant-to-dr-andrew-berical-of-boston-university-to-advance-research-into-gene-delivery-methods","status":"publish","type":"post","link":"https:\/\/www.emilysentourage.org\/tr\/emilys-entourage-awards-220000-research-grant-to-dr-andrew-berical-of-boston-university-to-advance-research-into-gene-delivery-methods\/","title":{"rendered":"Emily's Entourage, Boston \u00dcniversitesi'nden Dr. Andrew Berical'a Gen \u0130letim Y\u00f6ntemleri Ara\u015ft\u0131rmalar\u0131n\u0131 \u0130lerletmek i\u00e7in $220,000 Ara\u015ft\u0131rma Bursu Verdi"},"content":{"rendered":"

Ara\u015ft\u0131rma \u015fu konulara odaklanm\u0131\u015ft\u0131r <\/span><\/i>AAV vekt\u00f6rleri ve lipid nanopartik\u00fcller de dahil olmak \u00fczere gen iletim y\u00f6ntemlerinin etkinli\u011fini test etmek i\u00e7in kullan\u0131lmak \u00fczere k\u0131smen insanla\u015ft\u0131r\u0131lm\u0131\u015f fare hava yollar\u0131n\u0131n geli\u015ftirilmesi.<\/span><\/i><\/p>\n

\"\"

Andrew Berical, MD
Boston \u00dcniversitesi<\/p><\/div>\n

Lower Merion, PA - Kas\u0131m <\/b>20<\/b>, 2023<\/b> - Kistik fibrozis (KF) hastalar\u0131n\u0131n son 10%'si i\u00e7in yeni tedaviler ve tedavi ara\u015ft\u0131rmalar\u0131n\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3 kurulu\u015fu olan Emily's Entourage (EE), bug\u00fcn <\/span>$220,000<\/span> Boston \u00dcniversitesi Chobanian & Avedisian T\u0131p Fak\u00fcltesi G\u00f6\u011f\u00fcs Hastal\u0131klar\u0131 ve Kritik Bak\u0131m T\u0131bb\u0131'nda Yard\u0131mc\u0131 Do\u00e7ent Doktor Andrew Berical'a fon sa\u011flad\u0131. Hibe<\/span> gen terapisini test etmek i\u00e7in insan hava yolu epitel h\u00fccrelerinin in-vivo bir modelini geli\u015ftirmeye y\u00f6nelik ara\u015ft\u0131rmalar\u0131 desteklemektedir. <\/span><\/p>\n

Dr. Berical halen Rejeneratif T\u0131p Merkezi'nde \u00f6\u011fretim \u00fcyesi ve bilim insan\u0131 olarak g\u00f6rev yapmakta olup ara\u015ft\u0131rmalar\u0131 hava yolu hastal\u0131klar\u0131n\u0131n modellenmesinin yan\u0131 s\u0131ra KF ve primer siliyer diskinezi i\u00e7in potansiyel bir tedavi olarak h\u00fccresel rejenerasyonun rol\u00fcne odaklanmaktad\u0131r. Bu ara\u015ft\u0131rma projesinde <\/span>\"CFTR gen terapisi i\u00e7in in vivo insan hava yolu epitel h\u00fccreleri,<\/span><\/i>\"W1282X insan hava yolu epitel h\u00fccrelerini ve yeni bir insanla\u015ft\u0131r\u0131lm\u0131\u015f fare modelini kullanarak \u00e7e\u015fitli gen iletim y\u00f6ntemlerinin \u00f6n\u00fcndeki engelleri incelemeyi planl\u0131yor.<\/span><\/p>\n

Ara\u015ft\u0131rma teklifi, viral vekt\u00f6rlerin ve lipid nanopartik\u00fcllerin (LNP) insan hava yolu epitel h\u00fccrelerine mRNA iletme kabiliyetinin de\u011ferlendirilmesini ve insan hava yolunun belirli h\u00fccre tipleri i\u00e7in iletim ajan\u0131 tercihlerinin ve bu gen iletim teknolojilerinin uzun \u00f6m\u00fcrl\u00fcl\u00fc\u011f\u00fcn\u00fcn anla\u015f\u0131lmas\u0131n\u0131 i\u00e7ermektedir.<\/span><\/p>\n

EE'nin Bilimsel Ba\u015f Sorumlusu Dr. Chandra Ghose, \"Dr. Berical'i bu \u00e7\u0131\u011f\u0131r a\u00e7an ara\u015ft\u0131rmas\u0131nda desteklemekten gurur duyuyoruz\" dedi. \"Dr. Berical'in \u00f6nc\u00fc ara\u015ft\u0131rmas\u0131, yeni bir teknoloji yaratmay\u0131 ama\u00e7l\u0131yor. <\/span>in vivo<\/span><\/i> Gen terapisi da\u011f\u0131t\u0131m mekanizmalar\u0131n\u0131n test edilmesini kolayla\u015ft\u0131rmak i\u00e7in insan hava yolu epitel h\u00fccreleri modeli, \u015fu anda ilerlemenin \u00f6n\u00fcnde b\u00fcy\u00fck bir engel te\u015fkil etmektedir ve son 10%'dekiler de dahil olmak \u00fczere KF'li bireyler i\u00e7in yeni tedavilerin geli\u015ftirilmesini h\u0131zland\u0131rmak i\u00e7in kritik \u00f6neme sahiptir.\"<\/span><\/p>\n

Pluripotent k\u00f6k h\u00fccre y\u00f6nlendirmeli farkl\u0131la\u015fmalar konusundaki uzmanl\u0131ktan ve insan kaynakl\u0131 pluripotent k\u00f6k h\u00fccre (iPSC) t\u00fcrevli bazal h\u00fccrelerin fare hava yoluna nakledilmesindeki son geli\u015fmelerden yararlanan proje, gen da\u011f\u0131t\u0131m y\u00f6ntemlerinin etkinli\u011fini test etmek i\u00e7in k\u0131smen insanla\u015ft\u0131r\u0131lm\u0131\u015f bir fare hava yolu olu\u015fturmay\u0131 ama\u00e7lamaktad\u0131r. Ekip daha sonra bu sistemi, iki spesifik ajan\u0131n insan hava yolu epitel h\u00fccrelerine gen verme yetene\u011fini de\u011ferlendirmek i\u00e7in kullanacak: bir Adeno-Associated Virus (AAV) vekt\u00f6r\u00fc ve LNP'ler.\u00a0<\/span><\/p>\n

\"Emily's Entourage'\u0131n bu c\u00f6mert deste\u011fi, laboratuvar\u0131m\u0131z\u0131n KF ara\u015ft\u0131rmalar\u0131ndaki \u00f6nemli bir bo\u015flu\u011fu gidermesini sa\u011flayacak. \u0130nsan KF hava yolu epitel h\u00fccrelerini i\u00e7eren bir model sistem olu\u015fturarak, gen da\u011f\u0131t\u0131m mekanizmalar\u0131na ili\u015fkin anlay\u0131\u015f\u0131m\u0131z\u0131 geli\u015ftirebilir ve spesifik CFTR mutasyonlar\u0131na bak\u0131lmaks\u0131z\u0131n KF'li t\u00fcm bireylere fayda sa\u011flayabilecek mutasyon-agnostik tedavilerin \u00f6n\u00fcn\u00fc a\u00e7abiliriz\" dedi.<\/span><\/p>\n

Bu ara\u015ft\u0131rma sayesinde Dr. Berical ve ara\u015ft\u0131rma ekibi, KF alan\u0131ndaki \u00f6nemli bir bilgi bo\u015flu\u011funu doldurmay\u0131 ve nihayetinde KF'li t\u00fcm bireyler i\u00e7in etkili tedavilerin geli\u015ftirilmesine katk\u0131da bulunmay\u0131 umuyor.<\/span><\/p>\n

Emily's Entourage'\u0131n (EE) Hibe Program\u0131 Hakk\u0131nda\u00a0<\/b><\/p>\n

Emily's Entourage'\u0131n (EE) Hibe Program\u0131, mevcut mutasyon hedefli tedavilerden faydalanamayan kistik fibrozis (KF) hastalar\u0131 i\u00e7in ara\u015ft\u0131rma ve terap\u00f6tik geli\u015ftirmeyi h\u0131zland\u0131rmak amac\u0131yla hibe fonu sa\u011flamaktad\u0131r. EE, \u00e7eviri hibeleri, i\u015fbirli\u011fine dayal\u0131 hibeler ve klinik \u00f6ncesi ke\u015fif hibeleri dahil olmak \u00fczere \u00e7e\u015fitli hibe finansman mekanizmalar\u0131n\u0131n yan\u0131 s\u0131ra giri\u015fimci hay\u0131rseverlik yat\u0131r\u0131mlar\u0131 yoluyla da finansman sa\u011flamaktad\u0131r.<\/span><\/p>\n

EE bug\u00fcne kadar d\u00fcnyan\u0131n d\u00f6rt bir yan\u0131ndaki \u00e7ok disiplinli ekiplere milyonlarca dolar hibe vermi\u015f ve milyonlarca dolarl\u0131k devam finansman\u0131n\u0131n sa\u011flanmas\u0131na yard\u0131mc\u0131 olmu\u015ftur. Verilen hibeleri g\u00f6r\u00fcnt\u00fclemek i\u00e7in \u015fu adresi ziyaret edin <\/span>https:\/\/www.emilysentourage.org\/awarded-grants\/<\/span><\/a>. EE'nin finansman f\u0131rsatlar\u0131 hakk\u0131nda daha fazla bilgi edinmek i\u00e7in \u015fu adresi ziyaret edin <\/span>https:\/\/www.emilysentourage.org\/funding-opportunities\/<\/span><\/a>.\u00a0<\/span><\/p>\n

Emily'nin \u00c7evresi Hakk\u0131nda<\/b><\/p>\n

Emily's Entourage, mevcut mutasyon hedefli tedavilerden yararlanamayan kistik fibrozis (KF) pop\u00fclasyonunun son 10%'sindeki bireyler i\u00e7in yeni tedaviler ve bir tedavi i\u00e7in ara\u015ft\u0131rmalar\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3't\u00fcr. Emily's Entourage 2011 y\u0131l\u0131ndan bu yana milyonlarca dolarl\u0131k ara\u015ft\u0131rma hibesi vermi\u015f, \u015fu anda sat\u0131n al\u0131nan bir KF gen terapisi \u015firketini kurmu\u015f, klinik deneylere kat\u0131l\u0131m\u0131 h\u0131zland\u0131rmak i\u00e7in bir hasta kay\u0131t defteri ve klinik deney e\u015fle\u015ftirme program\u0131 geli\u015ftirmi\u015f ve y\u00fcksek etkili ara\u015ft\u0131rma ve ila\u00e7 geli\u015ftirmeye y\u00f6nelik d\u00fcnya \u00e7ap\u0131nda \u00e7abalara \u00f6nc\u00fcl\u00fck etmi\u015ftir. Kurulu\u015f, New York Times, STAT, CNN, People ve daha fazlas\u0131 dahil olmak \u00fczere ulusal medyada yer alm\u0131\u015ft\u0131r. Daha fazla bilgi i\u00e7in <\/span>emilysentourage.org<\/span><\/a>.<\/span><\/p>\n

Medya \u0130leti\u015fim<\/strong><\/p>\n

Emily'nin \u00c7evresi<\/span><\/p>\n

admin@emilysentourage.org<\/span><\/a><\/p>","protected":false},"excerpt":{"rendered":"

Ara\u015ft\u0131rma, AAV vekt\u00f6rleri ve lipid nanopartik\u00fcller de dahil olmak \u00fczere gen iletim y\u00f6ntemlerinin etkinli\u011fini test etmek i\u00e7in kullan\u0131lmak \u00fczere k\u0131smen insanla\u015ft\u0131r\u0131lm\u0131\u015f fare solunum yollar\u0131 geli\u015ftirmeye odaklanm\u0131\u015ft\u0131r. Lower Merion, PA - 20 Kas\u0131m 2023 - Emily's Entourage (EE), yeni tedaviler ve hastal\u0131\u011f\u0131n son 10%'si i\u00e7in bir tedavi ara\u015ft\u0131rmas\u0131n\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3... <\/p>\n

<\/div>\n

Daha fazla bilgi edinin<\/a><\/p>","protected":false},"author":1361,"featured_media":20020,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"%%sitetitle%% %%sep%% %%post_title%%","_seopress_titles_desc":"%%post_excerpt%%","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"none","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[178],"tags":[],"class_list":["post-20016","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-releases"],"acf":[],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Andrew-Barical-Headshot.jpg","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/20016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/users\/1361"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/comments?post=20016"}],"version-history":[{"count":5,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/20016\/revisions"}],"predecessor-version":[{"id":20527,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/20016\/revisions\/20527"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media\/20020"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media?parent=20016"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/categories?post=20016"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/tags?post=20016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}