{"id":17998,"date":"2022-12-15T12:49:40","date_gmt":"2022-12-15T17:49:40","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?p=17998"},"modified":"2023-12-20T05:15:23","modified_gmt":"2023-12-20T10:15:23","slug":"maria-limberis-phd-joins-emilys-entourage-scientific-advisory-board","status":"publish","type":"post","link":"https:\/\/www.emilysentourage.org\/tr\/maria-limberis-phd-joins-emilys-entourage-scientific-advisory-board\/","title":{"rendered":"Emily's Entourage, Maria P. Limberis, PhD'nin Bilimsel Dan\u0131\u015fma Kuruluna Eklendi\u011fini Duyurdu"},"content":{"rendered":"<h3><strong><i>Hava yolu gen terapisi ara\u015ft\u0131rmalar\u0131na adanm\u0131\u015f kariyerinde Dr. Limberis, lentiviral tabanl\u0131 gen terapisinin hastal\u0131\u011f\u0131n hayvan modelinde KF hava yolu kusurunu \"d\u00fczeltti\u011fini\" g\u00f6steren ilk ki\u015fidir.<\/i><\/strong><\/h3>\n<div id=\"attachment_17979\" style=\"width: 396px\" class=\"wp-caption alignright\"><img fetchpriority=\"high\" decoding=\"async\" aria-describedby=\"caption-attachment-17979\" class=\"wp-image-17979\" src=\"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Maria-Limberis_received-11-14-22-300x247.jpeg\" alt=\"\" width=\"386\" height=\"318\" srcset=\"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Maria-Limberis_received-11-14-22-300x247.jpeg 300w, https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Maria-Limberis_received-11-14-22-1024x843.jpeg 1024w, https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Maria-Limberis_received-11-14-22-768x632.jpeg 768w, https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Maria-Limberis_received-11-14-22-1536x1264.jpeg 1536w, https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Maria-Limberis_received-11-14-22-2048x1686.jpeg 2048w, https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Maria-Limberis_received-11-14-22-15x12.jpeg 15w, https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Maria-Limberis_received-11-14-22-600x494.jpeg 600w\" sizes=\"(max-width: 386px) 100vw, 386px\" \/><p id=\"caption-attachment-17979\" class=\"wp-caption-text\">Maria Limberis, PhD, Emily's Entourage i\u00e7in Bilimsel Dan\u0131\u015fma Kuruluna kat\u0131ld\u0131<\/p><\/div>\n<p>Nonsense mutasyonlar\u0131 olanlar da dahil olmak \u00fczere kistik fibrozis (KF) hastalar\u0131n\u0131n son 10%'si i\u00e7in yeni tedaviler ve tedavi ara\u015ft\u0131rmalar\u0131n\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3 vakf\u0131 olan Emily's Entourage (EE), bug\u00fcn Bilimsel Dan\u0131\u015fma Kurulu'na (SAB) Maria P. Limberis, PhD'nin eklendi\u011fini duyurdu. Dr. Limberis, KF ara\u015ft\u0131rma ve bak\u0131m\u0131nda en iyi ara\u015ft\u0131rmac\u0131lar, klinisyenler ve sa\u011fl\u0131k sekt\u00f6r\u00fc liderlerinden olu\u015fan bir grup olan di\u011fer 9 SAB \u00fcyesine kat\u0131l\u0131yor. SAB, EE'nin \u015fu anda mevcut tedavilerden yararlanamayan KF'li insanlar i\u00e7in hayat kurtaran at\u0131l\u0131mlar\u0131 h\u0131zland\u0131rma hedefini ilerletmek i\u00e7in bilimsel ve klinik projelerin belirlenmesi, de\u011ferlendirilmesi ve kolayla\u015ft\u0131r\u0131lmas\u0131nda kritik bir rol oynamaktad\u0131r.<\/p>\n<p>Dr. Limberis ara\u015ft\u0131rma kariyerini KF hava yolu hastal\u0131\u011f\u0131n\u0131n potansiyel tedavisi i\u00e7in yeni gen terapilerinin ke\u015ffi ve geli\u015ftirilmesine adam\u0131\u015ft\u0131r. Avustralya'n\u0131n Adelaide kentindeki Adelaide \u00dcniversitesi ve Kad\u0131n ve \u00c7ocuk Hastanesi'nde y\u00fcr\u00fctt\u00fc\u011f\u00fc doktora ara\u015ft\u0131rmas\u0131 s\u0131ras\u0131nda Dr. Limberis, KF'den etkilenen akci\u011ferler i\u00e7in, akci\u011ferlerde do\u011fal olarak bulunan ve hastal\u0131kl\u0131 hava yolu h\u00fccrelerinin terap\u00f6tik KF genini almas\u0131n\u0131 sa\u011flamak i\u00e7in akci\u011ferleri 'ko\u015fulland\u0131ran' bir bile\u015fi\u011fi i\u00e7eren yeni bir gen terapisi rejimi geli\u015ftirmi\u015ftir. Sonu\u00e7lar, \u015fu dergide yay\u0131nland\u0131 <em>\u0130nsan Gen Terapisi<\/em> 2002 y\u0131l\u0131nda, lentiviral bazl\u0131 gen terapisinin bir KF hayvan modelinde KF hava yolu defektini \"d\u00fczeltti\u011fini\" ilk kez g\u00f6stermi\u015flerdir. Bu ara\u015ft\u0131rma bir\u00e7ok gen terapisi \u00e7al\u0131\u015fmas\u0131n\u0131n temelini olu\u015fturmu\u015f ve 155'ten fazla yay\u0131nda at\u0131fta bulunulmu\u015ftur.<\/p>\n<p>Emily's Entourage'\u0131n Bilimsel Ba\u015f Sorumlusu Chandra Ghose, \"Dr. Limberis'in kapsaml\u0131 gen terapisi ara\u015ft\u0131rma deneyimi, KF'li ki\u015filerin son 10%'si i\u00e7in tedavilerin geli\u015ftirilmesine y\u00f6nelik aray\u0131\u015f\u0131m\u0131z\u0131 s\u00fcrd\u00fcr\u00fcrken SAB'\u0131m\u0131za \u00f6nemli bir katk\u0131d\u0131r\" dedi. \"KF'li hi\u00e7 kimsenin, \u00f6zellikle de nonsense ve nadir KF mutasyonlar\u0131na sahip olanlar\u0131n etkili tedavi se\u00e7eneklerinden yoksun kalmamas\u0131n\u0131 sa\u011flamak i\u00e7in gen temelli y\u00f6ntemleri ara\u015ft\u0131rmak kritik \u00f6nem ta\u015f\u0131yor. Misyonumuzu desteklemek \u00fczere Dr. Limberis'in bu alandaki uzmanl\u0131\u011f\u0131n\u0131 dan\u0131\u015fman ekibimize katmaktan heyecan duyuyoruz.\"<\/p>\n<p>Dr. Limberis halen Spirovant Sciences, Inc. \u015firketinde Ara\u015ft\u0131rma Ba\u015fkan Yard\u0131mc\u0131s\u0131 olarak g\u00f6rev yapmaktad\u0131r. Daha \u00f6nce Pennsylvania \u00dcniversitesi T\u0131p B\u00f6l\u00fcm\u00fc'nde Ara\u015ft\u0131rma Do\u00e7enti olarak g\u00f6rev yapm\u0131\u015f ve KF ve hava yoluyla bula\u015fan enfeksiyon hastal\u0131klar\u0131nda preklinik Ar-Ge ve translasyonel gen terapisi programlar\u0131na liderlik etmi\u015ftir.<\/p>\n<p>Dr. Limberis, \"Emily's Entourage'\u0131n SAB'\u0131na kat\u0131lmaktan b\u00fcy\u00fck mutluluk duyuyorum ve KF'li t\u00fcm hastalar i\u00e7in bir tedavi bulma misyonuna katk\u0131da bulunmay\u0131 d\u00f6rt g\u00f6zle bekliyorum\" dedi.<\/p>\n<p>Dr. Limberis, Bilimsel Dan\u0131\u015fma Kurulu'nda a\u015fa\u011f\u0131daki \u00fcyelere kat\u0131lmaktad\u0131r:<\/p>\n<ul>\n<li>David M. Bedwell, PhD<\/li>\n<li>Jennifer Bomberger, PhD<\/li>\n<li>Kevin Foskett, PhD (y\u00f6netim kurulu ba\u015fkan\u0131)<\/li>\n<li>Denis Hadjiliadis, MD<\/li>\n<li>Patrick Harrison, PhD<\/li>\n<li>Batsheva Kerem, PhD<\/li>\n<li>Jennifer Taylor-Cousar, MD, MSCS, ATSF<\/li>\n<li>Ted J. Torphy, PhD<\/li>\n<li>David B. Weiner, PhD<\/li>\n<\/ul>\n<p style=\"text-align: center;\"><span style=\"text-align: center;\">###<\/span><\/p>\n<p><b>Emily'nin \u00c7evresi Hakk\u0131nda<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Emily's Entourage, KF'nin nonsense mutasyonlar\u0131na sahip olanlar da dahil olmak \u00fczere mevcut mutasyon hedefli tedavilerden fayda g\u00f6rmeyen kistik fibrozis (KF) pop\u00fclasyonunun son 10%'sindeki bireyler i\u00e7in yeni tedaviler ve bir tedavi i\u00e7in ara\u015ft\u0131rmalar\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3't\u00fcr. Emily's Entourage 2011 y\u0131l\u0131ndan bu yana milyonlarca dolarl\u0131k ara\u015ft\u0131rma hibesi vermi\u015f, \u015fu anda sat\u0131n al\u0131nan bir KF gen terapisi \u015firketini kurmu\u015f, klinik deneylere kat\u0131l\u0131m\u0131 h\u0131zland\u0131rmak i\u00e7in bir hasta kay\u0131t defteri ve klinik deney e\u015fle\u015ftirme program\u0131 geli\u015ftirmi\u015f ve y\u00fcksek etkili ara\u015ft\u0131rma ve ila\u00e7 geli\u015ftirmeyi te\u015fvik etmek i\u00e7in d\u00fcnya \u00e7ap\u0131nda \u00e7abalara \u00f6nc\u00fcl\u00fck etmi\u015ftir. Kurulu\u015f, New York Times, STAT, CNN, People ve daha fazlas\u0131 dahil olmak \u00fczere ulusal medyada yer alm\u0131\u015ft\u0131r. Daha fazla bilgi i\u00e7in <\/span><a href=\"https:\/\/www.emilysentourage.org\/tr\/\"><span style=\"font-weight: 400;\">emilysentourage.org<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><b>Medya \u0130leti\u015fim<\/b><br \/>\nEmily'nin \u00c7evresi<br \/>\n<a href=\"mailto:admin@emilysentourage.org\" target=\"_blank\" rel=\"nofollow noopener\">admin@emilysentourage.org<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Hava yolu gen terapisi ara\u015ft\u0131rmalar\u0131na adanm\u0131\u015f kariyerinde Dr. Limberis, lentiviral tabanl\u0131 gen terapisinin hastal\u0131\u011f\u0131n hayvan modelinde KF hava yolu kusurunu \u201cd\u00fczeltti\u011fini\u201d g\u00f6steren ilk ki\u015fidir. Emily's Entourage (EE), KF hastalar\u0131n\u0131n son 10%'si i\u00e7in yeni tedaviler ve bir tedavi i\u00e7in ara\u015ft\u0131rmalar\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3 vakf\u0131... <\/p>\n<div class=\"clear\"><\/div>\n<p><a href=\"https:\/\/www.emilysentourage.org\/tr\/maria-limberis-phd-joins-emilys-entourage-scientific-advisory-board\/\" class=\"excerpt-read-more\">Daha fazla bilgi edinin<\/a><\/p>","protected":false},"author":1361,"featured_media":17979,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"%%post_title%%","_seopress_titles_desc":"  %%post_excerpt%%","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"none","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[{"_seopress_pro_rich_snippets_type":"none"}],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[178],"tags":[],"class_list":["post-17998","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-releases"],"acf":[],"jetpack_featured_media_url":"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Maria-Limberis_received-11-14-22.jpeg","jetpack_sharing_enabled":true,"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/17998","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/users\/1361"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/comments?post=17998"}],"version-history":[{"count":5,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/17998\/revisions"}],"predecessor-version":[{"id":20524,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/17998\/revisions\/20524"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media\/17979"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media?parent=17998"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/categories?post=17998"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/tags?post=17998"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}