{"id":17508,"date":"2022-11-02T08:02:54","date_gmt":"2022-11-02T12:02:54","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?page_id=17508"},"modified":"2023-12-20T05:15:53","modified_gmt":"2023-12-20T10:15:53","slug":"emilys-entourage-awards-220000-to-advance-the-development-of-phage-therapies-as-a-means-to-treat-multidrug-resistant-ntm-infections","status":"publish","type":"post","link":"https:\/\/www.emilysentourage.org\/tr\/emilys-entourage-awards-220000-to-advance-the-development-of-phage-therapies-as-a-means-to-treat-multidrug-resistant-ntm-infections\/","title":{"rendered":"Emily's Entourage, \u00c7ok \u0130laca Diren\u00e7li NTM Enfeksiyonlar\u0131n\u0131n Tedavisinde Bir Ara\u00e7 Olarak Faj Tedavilerinin Geli\u015ftirilmesi i\u00e7in $220,000 \u00d6d\u00fcl Verdi"},"content":{"rendered":"

Proje, faj tedavisinin t\u00fcberk\u00fcloz d\u0131\u015f\u0131 mikobakteri (NTM) enfeksiyonu olan kistik fibrozis hastalar\u0131nda tedavi olarak kullan\u0131m\u0131n\u0131 yayg\u0131nla\u015ft\u0131rmay\u0131 ama\u00e7lamaktad\u0131r<\/i>
\n<\/strong><\/em><\/h3>\n

Lower Merion, PA - 2 Kas\u0131m 2022 - Nonsense mutasyonlar\u0131 olanlar da dahil olmak \u00fczere kistik fibrozis (KF) hastalar\u0131n\u0131n son 10%'si i\u00e7in yeni tedaviler ve tedavi ara\u015ft\u0131rmalar\u0131n\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3 vakf\u0131 olan Emily's Entourage (EE), bug\u00fcn Graham F.'ye $220.000 fon verdi\u011fini duyurdu. Pittsburgh \u00dcniversitesi'nden PhD Hatfull, bakteriyofajlar\u0131n (bakterileri enfekte eden vir\u00fcsler) nont\u00fcberk\u00fcloz mikobakteri (NTM) enfeksiyonlar\u0131 i\u00e7in bir tedavi olarak kullan\u0131lmas\u0131na y\u00f6nelik ara\u015ft\u0131rmas\u0131n\u0131 desteklemek \u00fczere.<\/span><\/p>\n

\"\"

Pittsburgh \u00dcniversitesi'nden Graham F. Hatfull, NTM enfeksiyonu olan ki\u015filer i\u00e7in potansiyel bir tedavi se\u00e7ene\u011fi olarak faj olarak da bilinen bakteriyofajlar\u0131 ke\u015ffetmeyi ama\u00e7layan bir ara\u015ft\u0131rma y\u00fcr\u00fct\u00fcyor.<\/p><\/div>\n

Pulmoner bakteriyel enfeksiyonlar, \u00f6zellikle de ilaca diren\u00e7li enfeksiyonlar, KF'li ki\u015filerde hastal\u0131\u011f\u0131n ilerlemesine ve \u00f6l\u00fcm oran\u0131na neden olmaktad\u0131r. En k\u00f6t\u00fcleri aras\u0131nda, genellikle mevcut antibiyotiklere diren\u00e7li olan ve bir\u00e7ok nakil merkezinde bireyleri akci\u011fer naklinden diskalifiye edebilen NTM enfeksiyonlar\u0131 yer almaktad\u0131r. Ayr\u0131ca, bu enfeksiyonlar \u00f6zellikle ba\u011f\u0131\u015f\u0131kl\u0131k sistemini bask\u0131lay\u0131c\u0131 ila\u00e7lar alan nakil sonras\u0131 hastalarda daha vahim olabilir.<\/span><\/p>\n

Dr. Hatfull'un \"Kistik fibrozda NTM enfeksiyonlar\u0131n\u0131n bakteriyofaj tedavisi\" ba\u015fl\u0131kl\u0131 projesi, NTM enfeksiyonu olan ki\u015filer i\u00e7in potansiyel bir tedavi se\u00e7ene\u011fi olarak faj olarak da bilinen bakteriyofajlar\u0131 ke\u015ffetmeyi ama\u00e7lamaktad\u0131r. Fajlar bakteriyel konak\u00e7\u0131lar\u0131n\u0131 etkili bir \u015fekilde \u00f6ld\u00fcr\u00fcr, g\u00fc\u00e7l\u00fc g\u00fcvenlik profillerine sahiptir ve antibiyotiklerle birlikte kullan\u0131ld\u0131\u011f\u0131nda ek ve hatta sinerjik faydalar sa\u011flayabilir.\u00a0<\/span><\/p>\n

Emily's Entourage'\u0131n Ba\u015f Bilimsel Sorumlusu Chandra Ghose, \"Faj terapisi gibi geleneksel olmayan yakla\u015f\u0131mlar, bu \u00f6l\u00fcmc\u00fcl enfeksiyonlarla sava\u015fmak i\u00e7in \u00e7ok az se\u00e7ene\u011fi olan KF'li ki\u015filerde NTM gibi \u00e7oklu ilaca diren\u00e7li patojenlerle sava\u015fmak i\u00e7in yakla\u015f\u0131m silahlar\u0131m\u0131za katk\u0131da bulunuyor\" dedi. \"\u00c7oklu ilaca diren\u00e7li bakteriyel enfeksiyon vakalar\u0131 y\u0131ldan y\u0131la artmaya devam etti\u011finden, bu hibenin finanse edilmesinin \u00f6nemi KF alan\u0131n\u0131n \u00f6tesine uzan\u0131yor ve herkesin elini ta\u015f\u0131n alt\u0131na koymas\u0131n\u0131 gerektiriyor.\"<\/span><\/p>\n

Dr. Hatfull'un ekibi, di\u011fer tedavi se\u00e7eneklerini t\u00fcketmi\u015f olan KF'li ki\u015filerde NTM enfeksiyonlar\u0131n\u0131n tedavisinde merhametli kullan\u0131m i\u00e7in fajlar\u0131 belirlemeye, haz\u0131rlamaya ve sa\u011flamaya odaklanacakt\u0131r. Deneyimleri daha sonra faj taramas\u0131, haz\u0131rlanmas\u0131 ve stabilitesini optimize etmek i\u00e7in kullan\u0131lacakt\u0131r.\u00a0<\/span><\/p>\n

\"Bu, NTM tedavisinde bakteriyofajlar\u0131n terap\u00f6tik kullan\u0131m\u0131n\u0131 ilerletmek i\u00e7in muazzam bir f\u0131rsat. <\/span>Pittsburgh \u00dcniversitesi'nde Biyolojik Bilimler profes\u00f6r\u00fc olan Dr. Hatfull, \"Bu \u00e7al\u0131\u015fma, KF'li ki\u015filerde enfeksiyonlar\u0131n \u00f6nlenmesine yard\u0131mc\u0131 olmakla kalmayacak, ayn\u0131 zamanda potansiyel klinik faydalar\u0131 olan alternatif se\u00e7eneklerin bulunmad\u0131\u011f\u0131 KF'li ki\u015filerde faj tedavilerinin g\u00fcvenli\u011fini ve etkinli\u011fini de\u011ferlendirmek \u00fczere k\u00f6rlemesine klinik \u00e7al\u0131\u015fmalar\u0131n olu\u015fturulmas\u0131 i\u00e7in gereken bilgileri sa\u011flamaya yard\u0131mc\u0131 olacakt\u0131r\" dedi. \"Bu sadece potansiyel klinik faydalar\u0131 olan alternatif se\u00e7enekleri olmayan KF'li insanlara yard\u0131mc\u0131 olmakla kalmayacak, ayn\u0131 zamanda faj tedavilerinin g\u00fcvenli\u011fini ve etkinli\u011fini ve kullan\u0131mlar\u0131n\u0131 etkileyen \u00e7ok say\u0131da parametreyi de\u011ferlendirmek i\u00e7in k\u00f6r klinik deneyler kurmak i\u00e7in gereken bilgileri sa\u011flamaya yard\u0131mc\u0131 olacakt\u0131r.\"<\/span><\/p>\n

Bu \u00e7al\u0131\u015fma, KF'li bir\u00e7ok ki\u015fide faj tedavilerinin olumlu sonu\u00e7lar\u0131n\u0131 g\u00f6steren \u00f6nceki \u00f6n \u00e7al\u0131\u015fmalara dayanacakt\u0131r.<\/span><\/p>\n

Emily's Entourage'\u0131n finanse etti\u011fi hibeler hakk\u0131nda daha fazla bilgi i\u00e7in <\/span>www.emilysentourage.org\/awarded-grants<\/span><\/a>.\u00a0<\/span><\/p>\n

###<\/span><\/p>\n

Emily'nin \u00c7evresi Hakk\u0131nda<\/b><\/p>\n

Emily's Entourage, KF'nin nonsense mutasyonlar\u0131na sahip olanlar da dahil olmak \u00fczere mevcut mutasyon hedefli tedavilerden fayda g\u00f6rmeyen kistik fibrozis (KF) pop\u00fclasyonunun son 10%'sindeki bireyler i\u00e7in yeni tedaviler ve bir tedavi i\u00e7in ara\u015ft\u0131rmalar\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3't\u00fcr. Emily's Entourage 2011 y\u0131l\u0131ndan bu yana milyonlarca dolarl\u0131k ara\u015ft\u0131rma hibesi vermi\u015f, bir KF gen terapisi \u015firketi kurmu\u015f, klinik deneylere kat\u0131l\u0131m\u0131 h\u0131zland\u0131rmak i\u00e7in bir hasta kay\u0131t defteri ve klinik deney e\u015fle\u015ftirme program\u0131 geli\u015ftirmi\u015f ve d\u00fcnya \u00e7ap\u0131nda y\u00fcksek etkili ara\u015ft\u0131rma ve ila\u00e7 geli\u015ftirme \u00e7abalar\u0131na \u00f6nc\u00fcl\u00fck etmi\u015ftir. Kurulu\u015f, New York Times, STAT, CNN, People ve daha fazlas\u0131 dahil olmak \u00fczere ulusal medyada yer alm\u0131\u015ft\u0131r. Daha fazla bilgi i\u00e7in <\/span>emilysentourage.org<\/span><\/a>.\u00a0<\/span><\/p>\n

Medya \u0130leti\u015fim<\/b>
\nAshling Knight<\/span>
\nPazarlama ve \u0130leti\u015fim Direkt\u00f6r\u00fc<\/span>
\nEmily'nin \u00c7evresi<\/span>
\nashling@emilysentourage.org<\/span><\/a>\u00a0<\/span><\/p>","protected":false},"excerpt":{"rendered":"

Proje, t\u00fcberk\u00fcloz d\u0131\u015f\u0131 mikobakteri (NTM) enfeksiyonu olan kistik fibroz hastalar\u0131 i\u00e7in bir tedavi olarak faj tedavisinin kullan\u0131m\u0131n\u0131 geni\u015fletmeyi ama\u00e7lamaktad\u0131r Lower Merion, PA - 2 Kas\u0131m 2022 - Emily's Entourage (EE), kistik fibrozlu ki\u015filerin son 10%'si i\u00e7in yeni tedaviler ve bir tedavi i\u00e7in ara\u015ft\u0131rmalar\u0131 h\u0131zland\u0131ran yenilik\u00e7i bir 501(c)3 vakf\u0131... <\/p>\n

<\/div>\n

Daha fazla bilgi edinin<\/a><\/p>","protected":false},"author":1281,"featured_media":16426,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"Emily\u2019s Entourage Awards $220,000 to Advance the Development of Phage Therapies as a Means to Treat Multidrug-Resistant NTM Infections","_seopress_titles_desc":"The project seeks to expand the use of phage therapy as a treatment for cystic fibrosis patients with nontuberculosis mycobacterium (NTM) infections.","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"none","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[{"_seopress_pro_rich_snippets_type":"none"}],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[178],"tags":[],"class_list":["post-17508","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-releases"],"acf":[],"jetpack_featured_media_url":"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Emilys-Entourage-Logo_Website-Featured-Image.png","jetpack_sharing_enabled":true,"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/17508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/users\/1281"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/comments?post=17508"}],"version-history":[{"count":5,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/17508\/revisions"}],"predecessor-version":[{"id":20534,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/17508\/revisions\/20534"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media\/16426"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media?parent=17508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/categories?post=17508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/tags?post=17508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}