{"id":10720,"date":"2018-03-28T09:27:34","date_gmt":"2018-03-28T13:27:34","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?p=10720"},"modified":"2018-03-28T09:30:48","modified_gmt":"2018-03-28T13:30:48","slug":"ee-launches-organoid-screening-of-cystic-fibrosis-nonsense-mutation","status":"publish","type":"post","link":"https:\/\/www.emilysentourage.org\/tr\/ee-launches-organoid-screening-of-cystic-fibrosis-nonsense-mutation\/","title":{"rendered":"EE Kistik Fibrozis Nonsense Mutasyonunun Organoid Taramas\u0131n\u0131 Ba\u015flatt\u0131"},"content":{"rendered":"

Emily's Entourage bir y\u0131ll\u0131k bir \u00f6d\u00fcl verdi\u011fini duyurmaktan gurur duyar <\/span>ara\u015ft\u0131rma bursu <\/span>Hollanda, Utrecht \u00dcniversitesi T\u0131p Merkezi'nden Jeffrey Beekman, PhD'ye.<\/span><\/p>\n

\"\"

Resim Jeffrey Beekman, PhD'nin izniyle.<\/p><\/div>\n

Bu hibe, ki\u015fiselle\u015ftirilmi\u015f t\u0131bb\u0131n yeni bir s\u0131n\u0131r\u0131n\u0131 yans\u0131tmaktad\u0131r. Organoidler<\/a><\/strong>-veya mini organlar, bir KF hastas\u0131n\u0131n kendi ba\u011f\u0131rsak k\u00f6k h\u00fccrelerinden t\u00fcretilir ve belirli tedavilerin belirli mutasyonlar i\u00e7in i\u015fe yaray\u0131p yaramad\u0131\u011f\u0131n\u0131 tahmin etti\u011fi g\u00f6sterilmi\u015ftir. \u00a0<\/span><\/p>\n

Organoidlerin KF terap\u00f6tiklerine uygulanmas\u0131nda \u00f6nc\u00fc olan Dr. Be<\/span>ekman, mevcut ve ara\u015ft\u0131r\u0131lan k\u00fc\u00e7\u00fck molek\u00fcll\u00fc CFTR mod\u00fclat\u00f6rlerinin W1282X mutasyonu i\u00e7in etkili olup olmad\u0131\u011f\u0131n\u0131 de\u011ferlendirmek i\u00e7in organoidleri kullanacakt\u0131r.<\/span><\/p>\n

\"\"<\/p>\n

Bu proje \u00f6zellikle zaman a\u00e7\u0131s\u0131ndan hassast\u0131r \u00e7\u00fcnk\u00fc KF pop\u00fclasyonunun yakla\u015f\u0131k 90%'si i\u00e7in piyasada veya son a\u015fama geli\u015ftirmede oyunun kurallar\u0131n\u0131 de\u011fi\u015ftiren at\u0131l\u0131mlar bulunmaktad\u0131r. W1282X dahil olmak \u00fczere iki nonsense mutasyon kopyas\u0131na sahip bireyler, KF pop\u00fclasyonunun, geli\u015ftirilmekte olan mutasyon hedefli tedavilerin bulunmad\u0131\u011f\u0131 10%'sine aittir. Bunun gibi ila\u00e7 tarama programlar\u0131, di\u011fer KF mutasyonlar\u0131 i\u00e7in halihaz\u0131rda geli\u015ftirilmi\u015f veya geli\u015ftirilmekte olan ila\u00e7lar\u0131n sa\u00e7ma mutasyonlar i\u00e7in de fayda sa\u011flay\u0131p sa\u011flayamayaca\u011f\u0131n\u0131 de\u011ferlendirir - potansiyel olarak kalan 10% i\u00e7in yak\u0131n vadeli terap\u00f6tik \u00e7\u00f6z\u00fcmler tan\u0131mlar.<\/p>\n

\"\"Emily's Entourage'\u0131n \"Catalyst for the Cure<\/i><\/b><\/a><\/span>\" ara\u015ft\u0131rma kampanyas\u0131 kapsam\u0131nda y\u00fcr\u00fct\u00fclen bu proje, KF'nin sa\u00e7ma mutasyonlar\u0131 i\u00e7in hayat kurtaran tedavilerin geli\u015ftirilmesini h\u0131zland\u0131rmak amac\u0131yla vakf\u0131n d\u00fcnyaca \u00fcnl\u00fc bilim insanlar\u0131yla ortakl\u0131k kurma y\u00f6n\u00fcndeki stratejik yakla\u015f\u0131m\u0131n\u0131 desteklemektedir.<\/p>\n

Emily's Entourage, y\u0131ll\u0131k bir hibe program\u0131 da dahil olmak \u00fczere \u00e7e\u015fitli farkl\u0131 fon mekanizmalar\u0131 arac\u0131l\u0131\u011f\u0131yla ara\u015ft\u0131rma ve ila\u00e7 geli\u015ftirme i\u00e7in destek sa\u011flamaktad\u0131r. \u0130nan\u0131lmaz ba\u011f\u0131\u015f\u00e7\u0131lar\u0131n deste\u011fi sayesinde vak\u0131f, 2011 y\u0131l\u0131ndan bu yana KF'nin anlams\u0131z mutasyonlar\u0131 \u00fczerine yap\u0131lan ara\u015ft\u0131rmalara $2,7 milyon dolar\u0131n \u00fczerinde hibe vermi\u015ftir. Daha fazla bilgi edinmek i\u00e7in\u00a0\u00d6d\u00fcllendirilen Hibeler<\/a><\/strong> Sayfa.\u00a0<\/span><\/p>\n

Strateji: K\u00fct\u00fcphanede Gezinme: Terap\u00f6tik Molek\u00fcllerin Belirlenmesi ve Yeniden Tasarlanmas\u0131<\/i><\/span><\/p>","protected":false},"excerpt":{"rendered":"

Emily's Entourage, Hollanda, Utrecht \u00dcniversitesi T\u0131p Merkezi'nden Jeffrey Beekman, PhD'ye bir y\u0131ll\u0131k ara\u015ft\u0131rma bursu verdi\u011fini duyurmaktan gurur duyar. Bu hibe, ki\u015fiselle\u015ftirilmi\u015f t\u0131bb\u0131n yeni bir s\u0131n\u0131r\u0131n\u0131 yans\u0131tmaktad\u0131r. Organoidler -ya da mini organlar- KF hastas\u0131n\u0131n kendi ba\u011f\u0131rsak k\u00f6k h\u00fccrelerinden elde edilir ve belirli tedavilerin ba\u015far\u0131l\u0131 olup olmayaca\u011f\u0131n\u0131 \u00f6ng\u00f6rd\u00fc\u011f\u00fc g\u00f6sterilmi\u015ftir... <\/p>\n

<\/div>\n

Daha fazla bilgi edinin<\/a><\/p>","protected":false},"author":1284,"featured_media":10740,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-10720","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"jetpack_featured_media_url":"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Organoids2.jpg","jetpack_sharing_enabled":true,"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/10720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/users\/1284"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/comments?post=10720"}],"version-history":[{"count":5,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/10720\/revisions"}],"predecessor-version":[{"id":10754,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/posts\/10720\/revisions\/10754"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media\/10740"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/media?parent=10720"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/categories?post=10720"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/tr\/wp-json\/wp\/v2\/tags?post=10720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}