{"id":10720,"date":"2018-03-28T09:27:34","date_gmt":"2018-03-28T13:27:34","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?p=10720"},"modified":"2018-03-28T09:30:48","modified_gmt":"2018-03-28T13:30:48","slug":"ee-launches-organoid-screening-of-cystic-fibrosis-nonsense-mutation","status":"publish","type":"post","link":"https:\/\/www.emilysentourage.org\/sv\/ee-launches-organoid-screening-of-cystic-fibrosis-nonsense-mutation\/","title":{"rendered":"EE lanserar Organoid-screening av nonsensmutation vid cystisk fibros"},"content":{"rendered":"

Emily's Entourage \u00e4r stolta \u00f6ver att kunna meddela att de har tilldelats ett ett\u00e5rigt <\/span>forskningsanslag <\/span>till Jeffrey Beekman, PhD, vid University Medical Center, Utrecht, Nederl\u00e4nderna.<\/span><\/p>\n

\"\"

Bild med tillst\u00e5nd av Jeffrey Beekman, PhD.<\/p><\/div>\n

Detta anslag \u00e5terspeglar en ny gr\u00e4ns f\u00f6r individanpassad medicin. Organoider<\/a><\/strong>- eller miniorgan - h\u00e4rr\u00f6r fr\u00e5n en CF-patients egna tarmstamceller och har visat sig kunna f\u00f6ruts\u00e4ga om vissa behandlingar fungerar f\u00f6r vissa mutationer. \u00a0<\/span><\/p>\n

En pionj\u00e4r inom till\u00e4mpningen av organoider f\u00f6r CF-behandlingar, Dr. Be<\/span>ekman kommer att anv\u00e4nda organoider f\u00f6r att bed\u00f6ma om befintliga och unders\u00f6kta CFTR-modulatorer med sm\u00e5 molekyler \u00e4r effektiva f\u00f6r W1282X-mutationen.<\/span><\/p>\n

\"\"<\/p>\n

Detta projekt \u00e4r s\u00e4rskilt tidsk\u00e4nsligt eftersom det finns banbrytande genombrott p\u00e5 marknaden eller i sen utvecklingsfas f\u00f6r cirka 90% av CF-populationen. Individer med tv\u00e5 kopior av nonsensmutationer, inklusive W1282X, tillh\u00f6r de 10% av CF-populationen f\u00f6r vilka det inte finns n\u00e5gra mutationsinriktade behandlingar under utveckling. L\u00e4kemedelsscreeningprogram som detta utv\u00e4rderar om l\u00e4kemedel som redan har utvecklats eller som f\u00f6r n\u00e4rvarande utvecklas f\u00f6r andra CF-mutationer ocks\u00e5 kan vara till nytta f\u00f6r nonsensmutationer - vilket potentiellt kan identifiera kortsiktiga terapeutiska l\u00f6sningar f\u00f6r de \u00e5terst\u00e5ende 10%.<\/p>\n

\"\"En del av Emily's Entourage's \"Katalysator f\u00f6r botemedel<\/i><\/b><\/a><\/span>\"Detta projekt st\u00f6der stiftelsens strategiska tillv\u00e4gag\u00e5ngss\u00e4tt att samarbeta med v\u00e4rldsber\u00f6mda forskare f\u00f6r att p\u00e5skynda utvecklingen av livr\u00e4ddande behandlingar f\u00f6r nonsensmutationer av CF.<\/p>\n

Emily's Entourage ger st\u00f6d till forskning och l\u00e4kemedelsutveckling genom en rad olika finansieringsmekanismer, inklusive ett \u00e5rligt anslagsprogram. Tack vare st\u00f6d fr\u00e5n fantastiska donatorer har stiftelsen delat ut \u00f6ver $2,7 miljoner dollar till forskning om nonsensmutationer vid CF sedan 2011. F\u00f6r att l\u00e4ra dig mer, bes\u00f6k\u00a0Tilldelade bidrag<\/a><\/strong> sida.\u00a0<\/span><\/p>\n

Strategi: Bl\u00e4ddra i biblioteket: Identifiera och \u00e5teranv\u00e4nda terapeutiska molekyler<\/i><\/span><\/p>","protected":false},"excerpt":{"rendered":"

Emily's Entourage \u00e4r stolta \u00f6ver att kunna meddela att de har beviljat ett ett\u00e5rigt forskningsanslag till Jeffrey Beekman, PhD, vid University Medical Center, Utrecht, Nederl\u00e4nderna. Detta anslag \u00e5terspeglar en ny gr\u00e4ns f\u00f6r individanpassad medicin. Organoider - eller miniorgan - h\u00e4rr\u00f6r fr\u00e5n en CF-patients egna tarmstamceller och har visat sig kunna f\u00f6ruts\u00e4ga om vissa terapier \u00e4r l\u00e4mpliga f\u00f6r... <\/p>\n

<\/div>\n

L\u00e4s mer om<\/a><\/p>","protected":false},"author":1284,"featured_media":10740,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10720","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"jetpack_featured_media_url":"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Organoids2.jpg","jetpack_sharing_enabled":true,"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/sv\/wp-json\/wp\/v2\/posts\/10720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/sv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/sv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/sv\/wp-json\/wp\/v2\/users\/1284"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/sv\/wp-json\/wp\/v2\/comments?post=10720"}],"version-history":[{"count":5,"href":"https:\/\/www.emilysentourage.org\/sv\/wp-json\/wp\/v2\/posts\/10720\/revisions"}],"predecessor-version":[{"id":10754,"href":"https:\/\/www.emilysentourage.org\/sv\/wp-json\/wp\/v2\/posts\/10720\/revisions\/10754"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/sv\/wp-json\/wp\/v2\/media\/10740"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/sv\/wp-json\/wp\/v2\/media?parent=10720"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/sv\/wp-json\/wp\/v2\/categories?post=10720"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/sv\/wp-json\/wp\/v2\/tags?post=10720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}