{"id":18959,"date":"2023-05-31T10:51:41","date_gmt":"2023-05-31T14:51:41","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?page_id=18959"},"modified":"2026-10-01T17:43:41","modified_gmt":"2026-10-01T21:43:41","slug":"translational-grants","status":"publish","type":"page","link":"https:\/\/www.emilysentourage.org\/pt_br\/translational-grants\/","title":{"rendered":"Subven\u00e7\u00f5es Translacionais"},"content":{"rendered":"<div style=\"background-color: #462561; color: #ffffff; padding: 22px 26px; margin: 0 0 30px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0; font-size: 18px; font-weight: bold; color: #ffffff;\">Translational Grant Application Cycle<strong>\u2014Now Open<\/strong><\/p>\n<p>EE is currently accepting proposals for its <strong>2026 Translational Grant funding cycle<\/strong>. Applications are due <strong>November 15, 2026, at 11:59 p.m. PT<\/strong>.<\/p>\n<p>Please review the information below for eligibility, funding priorities, application guidelines, and submission details.<\/p>\n<p>Questions? Contact us at <a href=\"mailto:research@emilysentourage.org\"><strong>research@emilysentourage.org<\/strong><\/a>.<\/p>\n<\/div>\n<p><span style=\"font-weight: 400;\">Emily&#8217;s Entourage&#8217;s (EE) Translational Grant Program provides critical seed funding to innovative investigators with promising strategies that accelerate research and drug development for those in the final 10% of the CF community who do not benefit from CFTR modulators, including those with rare and nonsense mutations. <\/span><\/p>\n<p><b>For the 2026 cycle, EE will prioritize proposals that turn decisively toward clinical development and funding the development of technologies that already show promise. <\/b>EE is <em><strong>not<\/strong><\/em> looking to fund e<span style=\"font-weight: 400;\">arly screens intended to identify a lead or t<\/span><span style=\"font-weight: 400;\">arget identification or basic mechanistic studies without a defined therapeutic candidate.<\/span><\/p>\n<p><b>Potential areas of interest include, but are not limited to, the following:<\/b><b><\/b><\/p>\n<ul>\n<li aria-level=\"1\"><b>Gene Editing for Specific CF Nonsense Variants: <\/b><span style=\"font-weight: 400;\">Adenine base editing (ABE) and prime editing offer the possibility of durable correction of disease-causing CFTR variants. Many common CF nonsense variants (G542X, W1282X, R553X, R1162X) arise from a C\u2022G\u2192T\u2022A transition and are therefore chemically amenable to ABE. Priority questions include the minimum effective correction level in airway epithelium required for clinical benefit, elimination of bystander edits, editing efficiency across airway cell subtypes (basal versus differentiated cells), and the durability of correction in a continuously turning-over epithelium.\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li><b>Delivery of Genetic Therapies to the CF Airway: <\/b><span style=\"font-weight: 400;\">Delivery remains the primary unsolved problem in CF gene editing: the target organ is the lung and the CF airway is an obstructed, chronically inflamed, biofilm-laden environment that traps and degrades nanoparticle and viral payloads. EE is particularly interested in LNPs (aerosolization stability, mucus penetration, lung tropism of\u00a0 lipids, reduced immune activation, extended payload half-life and reduced dosing frequency) and engineered airway-tropic AAV capsids together with re-administration or immunosuppression strategies as well as systemic delivery strategies that have lung tropism.<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Antisense Oligonucleotide (ASO): <\/b><span style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Priorities include ASO lead selection and chemistry, GMP manufacturing, IND-enabling inhalation toxicology and off-target splice profiling, inhaled <\/span><\/span><span style=\"font-weight: 400;\">delivery to the CF airway, and the effects of combining an ASO with approved CFTR modulators.\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Screening Assays for Immunogenicity of Genetic Therapies in the CF Airway: <\/b><span style=\"font-weight: 400;\">Because airway epithelial cells turn over continuously, repeat dosing will almost certainly be required for any nucleotide based therapy. LNP components and viral capsids may lead to inflammation\/immune responses which may be amplified in the CF airway, already primed by chronic bacterial colonization and baseline inflammation. The field currently lacks validated, standardized assays to predict this immunogenicity. <\/span><span style=\"font-weight: 400;\">We are seeking proposals for screening assays that characterize and de-risk the immunogenicity of genetic therapies for CF, including but not limited to: innate immune activation panels in primary human CF airway epithelial cultures; assays performed under CF-relevant conditions (chronic inflammation, mucus, bacterial products) rather than in naive systems alone; and repeat-dose models that quantify loss of editing or transduction efficiency across sequential administrations.<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Small Molecules for Readthrough and Nonsense-Mediated Decay: <\/b><span style=\"font-weight: 400;\">Readthrough compounds and inhibitors of nonsense-mediated mRNA decay (NMD) are gene-independent, orally available approaches applicable across nonsense variants; the historical limitation has been potency. EE is interested in next-generation readthrough compounds, selective NMD modulators that have in vivo proof-of-concept.\u00a0<\/span><span style=\"font-weight: 400;\">We are looking to fund tissue distribution studies in CF models, assessment of the breadth of activity across multiple CF nonsense variants, and layered combinations of readthrough plus NMD inhibition plus modulators that could raise functional restoration into the therapeutically relevant range.<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Phage Therapy for CF Pathogens with a particular focus on MRSA: <\/b><span style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Chronic airway infection continues to drive lung function decline and mortality, including in people on modulators. Bacteriophage therapy is among the most promising anti-infective strategies for CF, and priority questions include the optimal use of cocktail compositions versus sequential single-phage dosing for MRSA, inhaled delivery achieving therapeutic concentrations in the distal airway, phage\u2013antibiotic combinations, emergence and management of phage resistance, <\/span><\/span><span style=\"font-weight: 400;\">and the data and protocols needed to move from compassionate use to formal clinical trials and timely patient access.<br \/>\n<\/span><\/li>\n<li aria-level=\"1\"><b>Antibiotics and Anti-Infectives: <\/b><span style=\"font-weight: 400;\">Superbugs such as MRSA are recovered from roughly a quarter of people with CF and are associated with accelerated lung function decline. Areas of interest include next-generation inhaled formulation of antibiotics such as Vancomycin with sustained pulmonary half-life and reduced bronchospasm risk. Our major priority is inhaled formulations that meet the needs of pwCF with chronic infections, including tolerability, safety, and suitability for long-term use.\u00a0<\/span><\/li>\n<\/ul>\n<h3><b>Key Deadlines<\/b><\/h3>\n<ul>\n<li><strong>Applications will be accepted beginning October 1, 2026, and are due by November 15, 2026 at 11:59 pm (PT).<br \/>\n<\/strong><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Applicants will be notified in December 2026 if they are selected to move to the next round.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Those applicants that move to the next round will have the opportunity to address concerns raised by external reviewers before a final funding decision is made.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Projected start date is April 2027.<\/span><\/li>\n<\/ul>\n<p>Please review <a href=\"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/2026-EE-Grant-Instructions-FINAL.docx.pdf\" target=\"_blank\" rel=\"noopener\">the 2026 grant application guidelines<\/a>\u00a0for complete submission requirements.<\/p>\n<p>If you have any questions or would like to discuss your interest in EE\u2019s funding opportunities, please feel free to contact us below.<\/p>\n<script>\nvar gform;gform||(document.addEventListener(\"gform_main_scripts_loaded\",function(){gform.scriptsLoaded=!0}),document.addEventListener(\"gform\/theme\/scripts_loaded\",function(){gform.themeScriptsLoaded=!0}),window.addEventListener(\"DOMContentLoaded\",function(){gform.domLoaded=!0}),gform={domLoaded:!1,scriptsLoaded:!1,themeScriptsLoaded:!1,isFormEditor:()=>\"function\"==typeof InitializeEditor,callIfLoaded:function(o){return!(!gform.domLoaded||!gform.scriptsLoaded||!gform.themeScriptsLoaded&&!gform.isFormEditor()||(gform.isFormEditor()&&console.warn(\"The use of gform.initializeOnLoaded() is 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Translacionais de 2026. As inscri\u00e7\u00f5es devem ser enviadas at\u00e9 15 de novembro de 2026, \u00e0s 23h59 (hor\u00e1rio da costa leste dos EUA). Por favor, consulte as informa\u00e7\u00f5es abaixo para conhecer os crit\u00e9rios de elegibilidade, as prioridades de financiamento, as diretrizes de inscri\u00e7\u00e3o e os detalhes de submiss\u00e3o. Tem alguma d\u00favida? Entre em contato conosco pelo e-mail research@emilysentourage.org. O Programa de Subs\u00eddios Translacionais da Emily\u2019s Entourage (EE) oferece financiamento crucial para\u2026 <\/p>\n<div class=\"clear\"><\/div>\n<p><a href=\"https:\/\/www.emilysentourage.org\/pt_br\/translational-grants\/\" class=\"excerpt-read-more\">Leia mais<\/a><\/p>","protected":false},"author":1361,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_seopress_titles_title":"%%sitetitle%% %%sep%% %%post_title%%","_seopress_titles_desc":"%%post_excerpt%%","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","_monsterinsights_skip_tracking":false,"footnotes":""},"class_list":["post-18959","page","type-page","status-publish","hentry"],"acf":[],"jetpack_sharing_enabled":true,"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/pt_br\/wp-json\/wp\/v2\/pages\/18959","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/pt_br\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/pt_br\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/pt_br\/wp-json\/wp\/v2\/users\/1361"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/pt_br\/wp-json\/wp\/v2\/comments?post=18959"}],"version-history":[{"count":10,"href":"https:\/\/www.emilysentourage.org\/pt_br\/wp-json\/wp\/v2\/pages\/18959\/revisions"}],"predecessor-version":[{"id":27233,"href":"https:\/\/www.emilysentourage.org\/pt_br\/wp-json\/wp\/v2\/pages\/18959\/revisions\/27233"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/pt_br\/wp-json\/wp\/v2\/media?parent=18959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}