{"id":10720,"date":"2018-03-28T09:27:34","date_gmt":"2018-03-28T13:27:34","guid":{"rendered":"https:\/\/www.emilysentourage.org\/?p=10720"},"modified":"2018-03-28T09:30:48","modified_gmt":"2018-03-28T13:30:48","slug":"ee-launches-organoid-screening-of-cystic-fibrosis-nonsense-mutation","status":"publish","type":"post","link":"https:\/\/www.emilysentourage.org\/es\/ee-launches-organoid-screening-of-cystic-fibrosis-nonsense-mutation\/","title":{"rendered":"EE lanza cribado organoide de mutaci\u00f3n sin sentido de fibrosis qu\u00edstica"},"content":{"rendered":"

Emily's Entourage se enorgullece de anunciar que ha otorgado un a\u00f1o <\/span>beca de investigaci\u00f3n <\/span>a Jeffrey Beekman, PhD, del Centro M\u00e9dico Universitario, Utrecht, Pa\u00edses Bajos.<\/span><\/p>\n

\"\"

Imagen cortes\u00eda de Jeffrey Beekman, PhD.<\/p><\/div>\n

Esta subvenci\u00f3n refleja una nueva frontera de la medicina personalizada. Organoides<\/a><\/strong>\u2014O mini \u00f3rganos\u2014 se derivan de las propias c\u00e9lulas madre intestinales de un paciente con FQ y se ha demostrado que predicen si ciertas terapias funcionan para mutaciones particulares. \u00a0<\/span><\/p>\n

Pionero en la aplicaci\u00f3n de organoides a la terap\u00e9utica de la FQ, el Dr. Be<\/span>ekman utilizar\u00e1 organoides para evaluar si los moduladores de CFTR de mol\u00e9cula peque\u00f1a actuales y en investigaci\u00f3n son eficaces para la mutaci\u00f3n W1282X.<\/span><\/p>\n

\"\"<\/p>\n

Este proyecto es particularmente sensible al tiempo porque hay avances revolucionarios en el mercado o en el desarrollo en etapa tard\u00eda para aproximadamente el 90% de la poblaci\u00f3n con FQ. Los individuos con dos copias de mutaciones sin sentido, incluido W1282X, pertenecen a la 10% perif\u00e9rica de la poblaci\u00f3n de FQ para la que no se est\u00e1n desarrollando tratamientos dirigidos a mutaciones. Los programas de detecci\u00f3n de drogas como este eval\u00faan si los medicamentos que ya se han desarrollado o se est\u00e1n desarrollando actualmente para otras mutaciones de la FQ tambi\u00e9n pueden proporcionar beneficios para las mutaciones sin sentido, lo que podr\u00eda identificar soluciones terap\u00e9uticas a corto plazo para el 10% restante.<\/p>\n

\"\"Parte de Emily's Entourage's "Catalyst for the Cure Grants<\/i><\/b><\/a><\/span>\u201d, Este proyecto apoya el enfoque estrat\u00e9gico de la fundaci\u00f3n de asociarse con cient\u00edficos de renombre mundial para acelerar el desarrollo de tratamientos que salvan vidas para mutaciones sin sentido de la FQ.<\/p>\n

Emily's Entourage brinda apoyo para la investigaci\u00f3n y el desarrollo de medicamentos a trav\u00e9s de una variedad de diferentes mecanismos de financiaci\u00f3n, incluido un programa de subvenciones anual. Gracias al apoyo de donantes incre\u00edbles, la fundaci\u00f3n ha otorgado m\u00e1s de $2.7 millones de d\u00f3lares para la investigaci\u00f3n de mutaciones sin sentido de la FQ desde 2011. Para obtener m\u00e1s informaci\u00f3n, visite el\u00a0Subvenciones otorgadas<\/a><\/strong> p\u00e1gina.\u00a0<\/span><\/p>\n

Estrategia: Explorando la biblioteca: identificaci\u00f3n y reutilizaci\u00f3n de mol\u00e9culas terap\u00e9uticas<\/i><\/span><\/p>","protected":false},"excerpt":{"rendered":"

Emily\u2019s Entourage is proud to announce that it has awarded a one-year research grant to Jeffrey Beekman, PhD, at the University Medical Center, Utrecht, Netherlands. This grant reflects a new frontier of personalized medicine. Organoids\u2014or mini organs\u2014are derived from a CF patient’s own intestinal stem cells and have been shown to predict whether certain therapies… <\/p>\n

<\/div>\n

Lee mas<\/a><\/p>","protected":false},"author":1284,"featured_media":10740,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-10720","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/www.emilysentourage.org\/wp-content\/uploads\/Organoids2.jpg","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.emilysentourage.org\/es\/wp-json\/wp\/v2\/posts\/10720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emilysentourage.org\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emilysentourage.org\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/es\/wp-json\/wp\/v2\/users\/1284"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/es\/wp-json\/wp\/v2\/comments?post=10720"}],"version-history":[{"count":5,"href":"https:\/\/www.emilysentourage.org\/es\/wp-json\/wp\/v2\/posts\/10720\/revisions"}],"predecessor-version":[{"id":10754,"href":"https:\/\/www.emilysentourage.org\/es\/wp-json\/wp\/v2\/posts\/10720\/revisions\/10754"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.emilysentourage.org\/es\/wp-json\/wp\/v2\/media\/10740"}],"wp:attachment":[{"href":"https:\/\/www.emilysentourage.org\/es\/wp-json\/wp\/v2\/media?parent=10720"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/es\/wp-json\/wp\/v2\/categories?post=10720"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emilysentourage.org\/es\/wp-json\/wp\/v2\/tags?post=10720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}